Why we like to drink: A functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol
Why we like to drink: A functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol
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DOI：
10.1523/jneurosci.0086-08.2008
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发表时间：
2008-04-30
影响因子：
5.3
通讯作者：
Hommer, Daniel W.
中科院分区：
文献类型：
--
作者：
Gilman, Jodi M.;Ramchandani, Vijay A.;Hommer, Daniel W.
人们通常喝酒来诱发欣快或减少焦虑，他们经常在社交场合喝酒，但酒精对涉及奖励和情绪的人类大脑回路的影响却很少被探索。我们给社交饮酒者静脉注射酒精，同时使用功能性磁共振成像（fMRI）测量大脑对视觉威胁和非威胁性面部刺激的反应。酒精强烈地激活了纹状体的奖赏回路，同时减弱了视觉和边缘系统对恐惧刺激的反应。醉酒的自我评价与纹状体激活，这表明在这个领域的激活可能有助于主观经验的愉悦和奖励在醉酒。这些结果表明，酒精的急性药理学奖励和抗焦虑作用可以用fMRI测量。
People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain response to visual threatening and nonthreatening facial stimuli was measured using functional magnetic resonance imaging (fMRI). Alcohol robustly activated striatal reward circuits while attenuating response to fearful stimuli in visual and limbic regions. Self-ratings of intoxication correlated with striatal activation, suggesting that activation in this area may contribute to subjective experience of pleasure and reward during intoxication. These results show that the acute pharmacological rewarding and anxiolytic effects of alcohol can be measured with fMRI.