Coupling of enantioselective biooxidation of dl-1,2-propanediol and bioreduction of pinacolone via regeneration cycle of coenzyme
Coupling of enantioselective biooxidation of dl-1,2-propanediol and bioreduction of pinacolone via regeneration cycle of coenzyme
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DOI：
10.1007/s00253-005-0231-3
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发表时间：
2006-02
影响因子：
5
通讯作者：
Keliang Gao;Q. Song;D. Wei
中科院分区：
文献类型：
--
作者：
Keliang Gao;Q. Song;D. Wei
首次报道了dl-1，2-丙二醇转化为2-羟基丙酸的对映选择性生物转化。在生物氧化过程中，会产生一些副产物，从而影响到e. e。酸的价值和产量。限制反应体系中的氧，并为反应体系提供额外的质子受体，显示出良好的效果。后一种方法构建了辅酶的再生循环系统。本文将频哪酮的生物还原与对映选择性氧化反应耦合起来。酸收率提高36%，e. e.产品价值接近99%。
Enantioselective biotransformation ofdl-1,2-propanediol tod-2-hydroxypropanic acid was first reported by the authors. In the biooxidation process, there were some by-product formed and thus influenced the e.e. value and output of the acid. Restricting oxygen in the reaction system and offering additional proton receptor to the system displayed approving effect. The latter method constructed regeneration cycle system of coenzyme. In the article, the bioreduction of pinacolone was coupled to the enantioselective oxidation. Yield of the acid was increased by 36% and e.e. value of the product approached 99%.