Increased choroidal thickness in adults with Down syndrome.
Increased choroidal thickness in adults with Down syndrome.
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DOI：
10.1002/dad2.12170
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Lengyel I
中科院分区：
文献类型：
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作者：
Csincsik L;Nelson R;Walpert MJ;Peto T;Holland A;Lengyel I
由于淀粉样蛋白前体蛋白（APP）基因的三倍复制，唐氏综合症（DS）患者特别容易患阿尔茨海默病（AD）。在这项横断面研究中，我们假设散发性AD （sAD）中报道的脉络膜变薄反映在成人DS患者中。采用光学相干断层成像技术对24例成人退行性痴呆患者和16例年龄匹配对照进行眼后极成像。测量并分析脉络膜厚度（ChT）与认知状态和大脑β淀粉样蛋白（Aβ）负荷的关系。与Ctrl组相比，DS组（pwDS组）的ChT增加。这种增加与性别差异有关，并与一小部分脑a β负荷呈正相关。没有发现ChT与年龄或认知状态有显著相关性。与sAD相比，本研究发现pwDS的脉络膜明显变厚。这些变化是否与DS的Aβ病理有关还有待进一步研究。
People with Down syndrome (DS) are particularly susceptible to Alzheimer's disease (AD) due to the triplication of the amyloid precursor protein (APP) gene. In this cross‐sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS. The posterior pole of the eye for 24 adults with DS and 16 age‐matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT) was measured and analyzed in relation to cognitive status and cerebral amyloid beta (Aβ) load. ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status. In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.