All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes.
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes.
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DOI：
10.3389/fimmu.2020.605024
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发表时间：
2020
影响因子：
7.3
通讯作者：
Li MMH
中科院分区：
文献类型：
--
作者：
Yang E;Li MMH
干扰素（IFN）信号传导诱导广泛的基因的表达，这些基因统称为IFN刺激基因（ISG），其通常起抑制病毒复制的作用。RNA病毒通常通过识别病毒复制中间体和与病毒基因组相关的分子特征或缺乏与宿主mRNA相关的分子特征而被ISG靶向。本文综述的ISG主要以RNA为中心的方式抑制病毒复制，致力于检测、降解或抑制病毒RNA的表达。这篇综述着重于剖析这些ISGs如何表现出多种抗病毒机制，通常通过使用不同的辅助因子，突出了I型IFN应答的复杂性。具体而言，这些ISG可以通过病毒RNA降解、病毒翻译抑制或两者来介导抗病毒作用。虽然OAS/RNase L途径全面降解RNA并阻止翻译，但ISG 20和ZAP采用靶向RNA降解和翻译抑制来阻断病毒复制。同时，SHFL通过抑制许多RNA病毒所需的-1核糖体移码来靶向翻译。最后，许多E3连接酶抑制病毒转录，这是在必须在翻译之前转录其基因组的反义RNA病毒的生命周期期间有吸引力的抗病毒靶标。通过这篇综述，我们的目标是提供一个更新的观点，这些ISG如何共同努力，形成一个复杂的网络的抗病毒武器库靶向病毒RNA过程。
Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication. RNA viruses are frequently targeted by ISGs through recognition of viral replicative intermediates and molecular features associated with viral genomes, or the lack of molecular features associated with host mRNAs. The ISGs reviewed here primarily inhibit viral replication in an RNA-centric manner, working to sense, degrade, or repress expression of viral RNA. This review focuses on dissecting how these ISGs exhibit multiple antiviral mechanisms, often through use of varied co-factors, highlighting the complexity of the type I IFN response. Specifically, these ISGs can mediate antiviral effects through viral RNA degradation, viral translation inhibition, or both. While the OAS/RNase L pathway globally degrades RNA and arrests translation, ISG20 and ZAP employ targeted RNA degradation and translation inhibition to block viral replication. Meanwhile, SHFL targets translation by inhibiting -1 ribosomal frameshifting, which is required by many RNA viruses. Finally, a number of E3 ligases inhibit viral transcription, an attractive antiviral target during the lifecycle of negative-sense RNA viruses which must transcribe their genome prior to translation. Through this review, we aim to provide an updated perspective on how these ISGs work together to form a complex network of antiviral arsenals targeting viral RNA processes.
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影响因子：
13
作者：
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通讯作者：
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影响因子：
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通讯作者：
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DOI：
10.1073/pnas.1302564110
发表时间：
2013-07-02
影响因子：
11.1
作者：
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通讯作者：
Hang, Howard C.
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影响因子：
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作者：
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通讯作者：
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