Oxytrifluoromethylation of multiple bonds using copper catalyst under mild conditions
Oxytrifluoromethylation of multiple bonds using copper catalyst under mild conditions
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DOI：
10.1016/j.tetlet.2012.07.134
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发表时间：
2012-10-10
影响因子：
1.8
通讯作者：
Sodeoka, Mikiko
中科院分区：
文献类型：
--
作者：
Egami, Hiromichi;Shimizu, Ryo;Sodeoka, Mikiko
研究了苯乙烯衍生物和炔烃在铜盐催化下与外、内氧亲核试剂的氧三氟甲基化反应。通过在布朗斯台德酸存在下的反应，还实现了由苯乙烯衍生物直接形成β-三氟甲基苯乙烯衍生物。进行氧三氟甲基化产物的进一步转化以证明其效用。(C)2012爱思唯尔有限公司保留所有权利。
Oxytrifluoromethylation reaction of styrene derivatives and alkynes with external and internal oxygen nucleophiles, catalyzed by copper (1) salts under mild conditions, was developed. Direct formation of a beta-trifluoromethylstyrene derivative from a styrene derivative was also achieved by the reaction in the presence of a Bronsted acid. Further transformation of the oxytrifluoromethylated products was conducted to demonstrate their utility. (C) 2012 Elsevier Ltd. All rights reserved.