Intracerebroventricular injection of microglia protects against focal brain ischemia
Intracerebroventricular injection of microglia protects against focal brain ischemia
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DOI：
10.1254/jphs.94.203
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发表时间：
2004-02-01
影响因子：
3.5
通讯作者：
Taniguchi, T
中科院分区：
文献类型：
--
作者：
Kitamura, Y;Takata, K;Taniguchi, T
小胶质细胞是脑实质中的巨噬细胞样吞噬细胞。然而，神经变性后小胶质细胞的功能尚未完全了解。在这项研究中，大脑中动脉（MCA）闭塞和再灌注造成大量的神经元损失，在大鼠大脑皮层和纹状体后3天。当大脑中动脉闭塞时，将外源性小胶质细胞显微注射到脑室内，神经退行性变的区域显著减少。此时，在缺血性病变中检测到迁移的小胶质细胞。这些结果表明，外源性小胶质细胞可以迁移到脑实质中，然后保护大脑中动脉闭塞和再灌注引起的神经退行性变。
Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA occlusion, neurodegenerative areas significantly decreased. At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion.