Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure
Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure
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DOI：
10.1016/j.cardfail.2019.09.001
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发表时间：
2020-08-01
影响因子：
6
通讯作者：
Anzai, Toshihisa
中科院分区：
文献类型：
--
作者：
Nakano, Ippei;Hori, Hiroaki;Anzai, Toshihisa
背景：心力衰竭（HF）患者的骨骼肌在数量和质量上均受到损害，这与运动能力降低密切相关。骨骼肌超声检查 (US) 已成为评估肌肉质量和数量的有用、无创工具。在这里，我们研究了基于超声回波强度 (EI) 的肌肉质量是否与心力衰竭患者的运动能力相关。方法和结果：对 58 名 HF 患者（61 +/- 12 岁）和 28 名对照受试者（58 +/- 14 岁）进行了研究。心力衰竭患者的股四头肌回声强度 (QEI) 显着高于对照组，股四头肌厚度 (QMT) 显着低于对照组（分别为 88.3 +/- 13.4 与 81.1 +/- 7.5，P= .010；5.21 +/- 1.10 与 6.54 +/- 1.34 cm，P< .001）。通过单变量分析，心衰组中 QEI 与年龄、峰值摄氧量 (VO2) 和纽约心脏协会分级显着相关。多变量分析显示，调整年龄、性别、体重指数和 QMT 后，QEI 与峰值摄氧量独立相关：b 系数 = -11.80，95% CI (-20.73，-2.86)，P = .011。结论：骨骼肌 EI 增强与心衰患者运动能力降低独立相关。 EI 的测量成本低、易于获取，适合评估与 HF 相关的骨骼肌质量变化。 （心脏衰竭杂志 2020；26：685-693）
Background: Skeletal muscle is quantitatively and qualitatively impaired in patients with heart failure (HF), which is closely linked to lowered exercise capacity. Ultrasonography (US) for skeletal muscle has emerged as a useful, noninvasive tool to evaluate muscle quality and quantity. Here we investigated whether muscle quality based on US-derived echo intensity (EI) is associated with exercise capacity in patients with HF. Methods and Results: Fifty-eight patients with HF (61 +/- 12 years) and 28 control subjects (58 +/- 14 years) were studied. The quadriceps femoris echo intensity (QEI) was significantly higher and the quadriceps femoris muscle thickness (QMT) was significantly lower in the patients with HF than the controls (88.3 +/- 13.4 vs 81.1 +/- 7.5, P= .010; 5.21 +/- 1.10 vs 6.54 +/- 1.34 cm, P< .001, respectively). By univariate analysis, QEI was significantly correlated with age, peak oxygen uptake (VO2), and New York Heart Association class in the HF group. A multivariable analysis revealed that the QEI was independently associated with peak VO2 after adjustment for age, gender, body mass index, and QMT: b-coefficient = -11.80, 95%CI (-20.73, -2.86), P= .011. Conclusion: Enhanced EI in skeletal muscle was independently associated with lowered exercise capacity in HF. The measurement of EI is low-cost, easily accessible, and suitable for assessment of HF-related alterations in skeletal muscle quality. (J Cardiac Fail 2020;26:685-693)