Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity.
Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity.
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DOI：
10.1016/j.resuscitation.2009.09.013
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发表时间：
2010-01
期刊：
影响因子：
6.5
通讯作者：
Gazmuri, Raul J.
中科院分区：
文献类型：
--
作者：
Ayoub, Iyad M.;Kolarova, Julieta;Gazmuri, Raul J.
关键词：
Episodes of ventricular fibrillation (VF) and myocardial dysfunction commonly occur after cardiac resuscitation compromising the return of stable circulation. We investigated in a pig model of VF whether limiting Na+-induced cytosolic Ca2+ overload using the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor cariporide promotes resuscitation with stable circulation. VF was electrically induced in 20 male pigs and left untreated for 6 minutes after which CPR was initiated and continued for 8 minutes before attempting defibrillation. Pigs were randomized to receive 3-mg/kg cariporide (n = 10) or 0.9%-NaCl (n = 10) before chest compression. Seven of 10 pigs in each group were successfully resuscitated and survived 2 hours. Cariporide ameliorated post-resuscitation ventricular ectopic activity such that fewer singlets (5 ± 5 vs 26 ± 21; p < 0.05) and fewer bigemini (1 ± 3 vs 33 ± 25; p < 0.05) were observed during the initial 5 minutes post-resuscitation. Additionally, cariporide-treated pigs did not require additional post-resuscitation shocks for ventricular tachycardia or recurrent VF (0.0 ± 0.0 vs 5.3 ± 7.8 shocks; p = 0.073). During the initial 60 minutes cariporide-treated pigs had higher), cardiac index (6.1 ± 0.7 vs 4.4 ± 1.1, L/min/m2; p < 0.01), left ventricular stroke work index (45 ± 9 vs 36 ± 10 gm·m/beat/m2; p < 0.05), and numerically higher mean aortic pressure (104 ± 11 vs 91 ± 12 mmHg; p = 0.054). Cariporide administered at the start of chest compression may help restore electrically and mechanically stable circulation after resuscitation from cardiac arrest.
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影响因子：
37.8
作者：
Ayoub, IM;Kolarova, J;Gazmuri, RJ
通讯作者：
Gazmuri, RJ
DOI：
10.1111/j.1540-8167.1995.tb00410.x
发表时间：
1995-05-01
影响因子：
2.7
作者：
IDRISS, SF;ANSTADT, MP;IDEKER, RE
通讯作者：
IDEKER, RE
影响因子：
3.3
作者：
Wang, Sufen;Radhakrishnan, Jeejabai;Gazmuri, Raul J.
通讯作者：
Gazmuri, Raul J.
影响因子：
9.5
作者：
Wirth, KJ;Maier, T;Busch, AE
通讯作者：
Busch, AE
影响因子：
37.8
作者：
Gazmuri, RJ;Ayoub, IM;Kolarova, JD
通讯作者：
Kolarova, JD