Non-Thermal Intervention of Lung Tumor by Core-Shell Magnetic Nanoparticles in a Magnetic Field
Non-Thermal Intervention of Lung Tumor by Core-Shell Magnetic Nanoparticles in a Magnetic Field
复制标题
核壳磁性纳米粒子在磁场中对肺肿瘤的非热干预
DOI：
10.3390/app11052003
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发表时间：
2021-03-01
影响因子：
2.7
通讯作者：
Qiu，Hao
中科院分区：
文献类型：
--
作者：
Zhang，Naming;Wang，Ziang;Qiu，Hao
K-RAS突变会导致正常细胞无法控制地分裂并变成癌症。由于缺乏有效针对这些突变的药物，目前患者的预后很差。本研究制备了磁性纳米颗粒，并对其进行了表征，并将其与磁场协同作用，干预肺肿瘤细胞的生长。通过数值计算，研究了模拟线圈的温升问题。分析了磁力作用下MNPs的非热效应。细胞实验显示，A549肿瘤细胞生长速度减慢。伤口愈合试验的结果也表明，肿瘤细胞的迁移受到抑制。与不加MNPs的磁刺激相比，MNPs增强了磁场的抑制作用。本研究提出了一种利用MNPs的非热效应治疗K-RAS诱导的肺癌的新方法，避免了热效应引起的副作用。
K-Ras mutations result in normal cells dividing uncontrollably and becoming cancerous. The prognosis is currently poor for patients due to the lack of drugs that can effectively target these mutations. In this study, magnetic nanoparticles (MNPs) were prepared, characterized, and cooperated with a magnetic field to intervene in the growth of lung tumor cells. The rise in temperature of a stimulation coil was studied by numerical calculation. The non-thermal effects of MNPs under a magnetic force were analyzed. The cell experiments showed that the growth of A549 tumor cells slowed down. The result of a wound-healing assay also indicated that the migration of tumor cells was suppressed. Compared with magnetic stimulation without MNPs, MNPs enhanced the inhibitory effects of a magnetic field. This study suggests a new way to treat K-Ras driven lung tumors using non-thermal effects of MNPs without the side effects caused by thermal effects.