Cyclooxygenase-2 (COX-2) polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population
Cyclooxygenase-2 (COX-2) polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population
复制标题
环加氧酶2（COX-2）rs689466多态性可能导致中国人群创伤后骨髓炎易感性增加
DOI：
10.1080/23744235.2017.1347816
复制
发表时间：
2017-01-01
影响因子：
5.8
通讯作者：
Yu, Bin
中科院分区：
文献类型：
--
作者：
Wang, Lei;Jiang, Nan;Yu, Bin
摘要背景：环氧合酶-2（考克斯-2）是炎症反应的主要介质之一，考克斯-2基因rs 20417和rs689466多态性与多种炎症性疾病相关。然而，这两种多态性与创伤后骨髓炎风险之间的潜在联系尚不清楚。本研究旨在探讨rs 20417和rs689466多态性与中国人群创伤后骨髓炎易感性之间的关系。研究方法：采用SNaPshot基因分型方法对189例确诊创伤后骨髓炎患者和220例健康对照者进行rs 20417和rs689466基因分型。采用卡方检验比较两组间基因型分布的差异以及5种不同遗传模型的结果。结果如下：通过隐性模型（GG vs. AA + AG）发现rs689466与创伤后骨髓炎之间存在显著相关性（OR = 1.74，95% CI：1.098-2.755，p = 0.018）。虽然通过等位基因模型（p = 0.098）或纯合子模型（p = 0.084）在两组之间没有发现rs689466的统计学差异，但结果显示等位基因G可能是中国人群中发生创伤后骨髓炎的危险因素，GG基因型的人可能具有更高的风险。然而，在这个中国队列中没有发现rs 20417与创伤后骨髓炎易感性之间的显著联系。结论：本研究首次报道了考克斯-2基因rs689466多态性与创伤后骨髓炎易感性的关系。
Abstract Background: Cyclooxygenase-2 (COX-2) enzyme is one of the major mediators during inflammation reactions, and COX-2 gene polymorphisms of rs20417 and rs689466 have been reported to be associated with several inflammatory diseases. However, potential links between the two polymorphisms and risk of developing post-traumatic osteomyelitis remain unclear. The present study aimed to investigate associations between the rs20417 and rs689466 polymorphisms and susceptibility to post-traumatic osteomyelitis in Chinese population. Methods: A total of 189 patients with definite diagnosis of post-traumatic osteomyelitis and 220 healthy controls were genotyped for rs20417 and rs689466 using the SNaPshot genotyping method. Chi-square test was used to compare differences of genotype distributions as well as outcomes of five different genetic models between the two groups. Results: Significant association was found between rs689466 and post-traumatic osteomyelitis by recessive model (GG vs. AA + AG) (OR = 1.74, 95% CI: 1.098–2.755, p = .018). Although no statistical differences were identified of rs689466 between the two groups by allele model (p = .098) or homozygous model (p = .084), outcomes revealed a tendency that allele G may be a risk factor and people of GG genotype may be in a higher risk to develop post-traumatic osteomyelitis in Chinese population. However, no significant link was found between rs20417 and susceptibility to post-traumatic osteomyelitis in this Chinese cohort. Conclusions: To our knowledge, we reported for the first time that COX-2 gene polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population.