Relation between circulating oxidized-LDL and metabolic syndrome in children with obesity: the role of hypertriglyceridemic waist phenotype
Relation between circulating oxidized-LDL and metabolic syndrome in children with obesity: the role of hypertriglyceridemic waist phenotype
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DOI：
10.1515/jpem-017-0239
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发表时间：
2017-12-01
影响因子：
1.4
通讯作者：
Cena, Hellas
中科院分区：
文献类型：
--
作者：
Calcaterra, Valeria;De Giuseppe, Rachele;Cena, Hellas
背景：氧化应激（OS）和代谢综合征（MetS）之间的关联已在成人中报道。我们分析了循环氧化低密度脂蛋白（Ox-LDL）和代谢综合征之间的关系，在儿科年龄，以确定是否血浆Ox-LDL水平与肥胖和是否氧化损伤，使用血清Ox-LDL水平作为代理，与代谢综合征。方法：我们招募了178名儿童（11.8 +/- 2.6岁）。根据体重指数（BMI）阈值，将受试者分为：正常体重BMI <第75百分位数;超重BMI 75- 97百分位数;肥胖BMI >第97百分位数。如果患者符合以下年龄和性别标准中的三个或更多个，则将其归类为患有MetS：BMI >第97百分位数、甘油三酯水平>第95百分位数、高密度脂蛋白（HDL）胆固醇水平<第5百分位数、收缩压（SBP）和/或舒张压（DBP）>第95百分位数和葡萄糖耐量受损。与正常和超重受试者相比，肥胖儿童的MetS患病率增加（p = 0.001），Ox-LDL水平更高（p < 0.05），Ox-LDL与MetS之间的关系有限（p = 0.06）。腰围/身高比（W/HtR）（p = 0.02）、甘油三酯（TG）（p = 0.001）和LDL-胆固醇（p < 0.001）是血浆Ox-LDL水平升高的独立预测因子。结论：氧化损伤与高脂血症腰围表型相关，可作为肥胖儿童代谢综合征和心脏代谢风险的早熟标志物。
Background: The association between oxidative stress (OS) and metabolic syndrome (MetS) has been reported in adults. We analyzed the relation between circulating oxidized low-density lipoproteins (Ox-LDL) and MetS in pediatric ages in order to define whether plasma Ox-LDL levels are correlated to obesity and whether oxidative damage, using serum Ox-LDL levels as a proxy, are associated with MetS.Methods: We enrolled 178 children (11.8 +/- 2.6 years). On the basis of a body mass index (BMI) threshold, the subjects were classified as: normal weight BMI < 75th percentile; overweight BMI 75-97th percentile; obese BMI > 97th percentile. Patients were classified as having MetS if they met three or more of the following criteria for age and sex: BMI > 97th percentile, triglyceride levels > 95th percentile, high-density lipoprotein (HDL) cholesterol level < 5th percentile, systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) > 95th percentile and impaired glucose tolerance.Results: Obese children showed increased MetS prevalence (p = 0.001) and higher Ox-LDL levels compared to normal-and overweight subjects (p < 0.05), with a limited relation between Ox-LDL and MetS (p = 0.06). Waist-to-height ratio (W/HtR) (p = 0.02), triglycerides (TG) (p = 0.001) and LDL-cholesterol (p < 0.001) resulted independent predictors of increased plasma Ox-LDL levels.Conclusions: Oxidative damage was correlated with a hypertriglyceridemic waist phenotype and can be a precocious marker of MetS and cardiometabolic risk in obese children.