Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma
Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma
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多环芳烃与环氧化物水解酶1之间的相互作用在哮喘中发挥作用
DOI：
10.1007/s10653-018-0201-1
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发表时间：
2019-02-01
影响因子：
4.2
通讯作者：
Huo，Xia
中科院分区：
文献类型：
--
作者：
Wang，Qihua;Xu，Xijin;Huo，Xia
哮喘是儿童和成人最常见的慢性疾病之一，是复杂的基因-环境相互作用的结果。多环芳烃（PAHs）作为一组广泛存在的环境有机污染物，参与了哮喘的发生、诱发和病理变化。研究表明，多环芳烃在哮喘的免疫变化、氧化应激和环境-基因相互作用中发挥重要作用，EPHX 1（环氧化物水解酶1，一种调节人体多环芳烃代谢的酶）可能通过影响多环芳烃代谢而与哮喘发生相关。本文综述了多环芳烃作为危险因素在哮喘发病中的作用;多环芳烃通过免疫和氧化应激改变参与哮喘发病的可能机制;多环芳烃与参与哮喘发病的EPHX 1-环氧水解酶1的相互作用，EPHX 1基因型/SNP/双倍型对EPHX 1-环氧水解酶1活性的影响，从而影响人体多环芳烃代谢和对多环芳烃暴露的易感性。本文综述了上述相互作用和哮喘的潜在机制，有助于提高公众对PAH控制的关注，并制定个体哮喘一级预防策略。
Asthma, as one of the most common chronic diseases in children and adults, is a consequence of complex gene–environment interactions. Polycyclic aromatic hydrocarbons (PAHs), as a group of widespread environmental organic pollutants, are involved in the development, triggering and pathologic changes of asthma. Various previous studies reported the critical roles of PAHs in immune changes, oxidative stress and environment–gene interactions of asthma.EPHX1(the gene of epoxide hydrolase 1, an enzyme mediating human PAH metabolism) had a possible association with asthma by influencing PAH metabolism. This review summarized that (1) the roles of PAHs in asthma—work as risk factors; (2) the possible mechanisms involved in PAH-related asthma—through immunologic and oxidative stress changes; (3) the interactions between PAHs andEPHX1involved in asthma—enzymatic activity of epoxide hydrolase 1, which affected byEPHX1genotypes/SNPs/diplotypes, could influence human PAH metabolism and people’s vulnerability to PAH exposure. This review provided a better understanding of the above interactions and underlying mechanisms for asthma which help to raise public’s concern on PAH control and develop strategies for individual asthma primary prevention.