Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy
Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy
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DOI：
10.1038/sj.eye.6702138
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发表时间：
2006-12-01
期刊：
影响因子：
3.9
通讯作者：
Sizmaz, S.
中科院分区：
文献类型：
--
作者：
Demircan, N.;Safran, B. G.;Sizmaz, S.
我们测量了增生性糖尿病视网膜病变（PDR）患者玻璃体液和血清中的白细胞介素-1 β（IL- 1 β）和肿瘤坏死因子-α（TNF-α），以确定这些细胞因子在疾病发病机制中的作用。玻璃体和血清样本收集自21名接受睫状体平坦部玻璃体切除术的PDR患者。对照玻璃体样品获自尸体，对照血清样品获自健康受试者。酶联免疫吸附法测定细胞因子。PDR患者血清IL-1 β和TNF-α浓度高于对照组（P < 0.05）。我们认为玻璃体IL- 1 β和TNF-α水平的增加可能在PDR的发病机制中起重要作用，PDR的特征是异常细胞增殖和新生血管形成。
We measured interleukin- 1 beta (IL- 1 beta) and tumour necrosis factor- alpha (TNF-alpha) in the vitreous humour and serum of patients with proliferative diabetic retinopathy (PDR), in order to determine the role of these cytokines in the pathogenesis of the disease. Vitreous and serum samples were collected from 21 patients with PDR who were undergoing pars plana vitrectomy. Control vitreous samples were obtained from cadavers and control serum samples from healthy subjects. The cytokines were measured by enzyme-linked immunosorbent assay. Vitreous IL- 1 beta and TNF-alpha concentrations in patients with PDR exceeded those of controls (P < 0.05), as did serum IL- 1 beta and TNF-alpha. We suggest that increased vitreous IL- 1 beta and TNF-alpha levels may play a significant role in the pathogenesis of PDR, which features abnormal cell proliferation and neovascularisation.