Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults
Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults
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DOI：
10.1016/j.vaccine.2006.04.060
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发表时间：
2006-08-14
期刊：
影响因子：
5.5
通讯作者：
Dekker, Cornelia L.
中科院分区：
文献类型：
--
作者：
Klein, Nicola P.;Holmes, Tyson H.;Dekker, Cornelia L.
潜伏的水痘带状疱疹病毒 (VZV) 可重新激活并引起带状疱疹，其预防依赖于对 VZV 的细胞免疫。为了评估健康自然免疫成年人中 VZV 细胞介导的免疫的时间变化，我们对 25 名成年人中每人一年内的 VZV 特异性反应细胞频率 (RCF) 进行了纵向评估。检测到 VZV 特异性 CD4+ T 细胞 (p < 0.003)，并且 RCF 的变异性极小。对 VZV T 细胞 RCF 的额外分析揭示了性别之间的差异，通过这种方法，只有男性 (p < 0.005) 具有可检测到的 VZV 特异性记忆 CD4+ T 细胞反应。总而言之，结果表明，可能有必要对年轻人和女性使用改良的高效减毒活 VZV 疫苗进行免疫接种进行进一步研究。 (c) 2006 Elsevier Ltd. 保留所有权利。
Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over I year in each of 25 adults. VZV-specific CD4+ T cells were detected (p < 0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p < 0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted. (c) 2006 Elsevier Ltd. All rights reserved.