CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance
CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance
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DOI：
10.1109/jssc.2009.2017007
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发表时间：
2009-05-01
影响因子：
5.4
通讯作者：
Ham, Donhee
中科院分区：
文献类型：
--
作者：
Sun, Nan;Liu, Yong;Ham, Donhee
我们报告了一种 CMOS RF 收发器，其设计用于检测癌症标记蛋白等生物物体。其主要功能是通过核磁共振（NMR）操纵和监测水中质子的射频动力学。目标物体改变质子动力学，这是我们生物传感的基础。 RF 收发器的测量接收器噪声系数为 0.7 dB。这种高灵敏度使得能够在 2 千克便携式平台中围绕 RF 收发器构建整个 NMR 系统，该平台比最先进的商用台式系统轻 60 倍，小 40 倍，但质量敏感度高 60 倍。我们的系统在 5 μL 样品量中检测 20 fmol 和 1.4 ng 亲和素（蛋白质），代表了电路设计人员在便携式平台中追求低成本诊断的方法。
We report on a CMOS RF transceiver designed for detection of biological objects such as cancer marker proteins. Its main function is to manipulate and monitor RF dynamics of protons in water via nuclear magnetic resonance (NMR). Target objects alter the proton dynamics, which is the basis for our biosensing. The RF transceiver has a measured receiver noise figure of 0.7 dB. This high sensitivity enabled construction of an entire NMR system around the RF transceiver in a 2-kg portable platform, which is 60 times lighter, 40 times smaller, yet 60 times more mass sensitive than a state-of-the-art commercial benchtop system. Sensing 20 fmol and 1.4 ng of avidin (protein) in a 5 mu L sample volume, our system represents a circuit designer's approach to pursue low-cost diagnostics in a portable platform.