A new look at electrolyte transport in the distal tubule.
A new look at electrolyte transport in the distal tubule.
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DOI：
10.1146/annurev-physiol-020911-153225
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发表时间：
2012
影响因子：
18.2
通讯作者：
Peti-Peterdi J
中科院分区：
文献类型：
--
作者：
Eladari D;Chambrey R;Peti-Peterdi J
远端肾单位在肾内稳态的控制中起着关键作用。直到最近，大多数研究都集中在集合管主细胞对Na+、K+和水的平衡的控制，以及肾素-血管紧张素-醛固酮系统的激素和抗利尿激素对溶质和水的调节。然而，最近的研究揭示了肾间质细胞的意想不到的重要性，这是存在于连接小管和集合管的一种细胞亚型。这种细胞最初被认为只参与酸碱调节。然而，现在清楚的是，嵌入的细胞吸收了氯化钠和K+，因此可能参与了血压和钾平衡的调节。我们强调的第二个挑战范式的概念是局部旁分泌因素的重要性正在显现，这些因素在肾脏控制水和电解质平衡方面发挥着关键作用。
The distal nephron plays a critical role in the renal control of homeostasis. Until very recently most studies focused on the control of Na+, K+, and water balance by principal cells of the collecting duct and the regulation of solute and water by hormones from the renin-angiotensin-aldosterone system and by antidiuretic hormone. However, recent studies have revealed the unexpected importance of renal intercalated cells, a subtype of cells present in the connecting tubule and collecting ducts. Such cells were thought initially to be involved exclusively in acid-base regulation. However, it is clear now that intercalated cells absorb NaCl and K+ and hence may participate in the regulation of blood pressure and potassium balance. The second paradigm-challenging concept we highlight is the emerging importance of local paracrine factors that play a critical role in the renal control of water and electrolyte balance.