Re-emergence of fatal human influenza A subtype H5N1 disease.
Re-emergence of fatal human influenza A subtype H5N1 disease.
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DOI：
10.1016/s0140-6736(04)15595-5
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发表时间：
2004-02-21
期刊：
影响因子：
--
通讯作者：
Guan Y
中科院分区：
文献类型：
--
作者：
Peiris JS;Yu WC;Leung CW;Cheung CY;Ng WF;Nicholls JM;Ng TK;Chan KH;Lai ST;Lim WL;Yuen KY;Guan Y
与甲型H5N1亚型流感有关的人类疾病于2003年1月再次出现，这是自1997年香港爆发疫情以来的第一次。H5N1疾病患者的血清趋化因子浓度异常高(如干扰素诱导蛋白-10和干扰素γ诱导的单核细胞因子)。结合H5N1流感病毒在体外培养巨噬细胞诱导大量促炎细胞因子的报道，我们的发现提示细胞因子功能障碍在H5N1疾病的发病机制中起作用。应优先发展针对甲型H5N1流感病毒的疫苗。
Human disease associated with influenza A subtype H5N1 reemerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon γ [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflam-matory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.