Neural precursor cells and central nervous system radiation sensitivity.
Neural precursor cells and central nervous system radiation sensitivity.
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DOI：
10.1016/j.semradonc.2008.12.003
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发表时间：
2009-04
影响因子：
3.5
通讯作者：
Limoli, Charles L.
中科院分区：
文献类型：
--
作者：
Fike, John R.;Rosi, Susanna;Limoli, Charles L.
正常脑组织的耐受性限制了在颅放射治疗期间可以安全递送的辐射剂量，并且可能出现的潜在并发症之一涉及认知障碍。最近出现的大量实验室数据表明，海马神经发生受到辐射的显着影响，这种变化与认知功能的改变有关，部分涉及微环境的变化（氧化应激，炎症）。虽然有相当大的不确定性，这些变化究竟是如何演变的，新的体外和体内方法提供了一种手段，通过这种手段，新的机制的见解，可以获得相关的主题。总之，从细胞培养和动物为基础的研究数据提供了补充信息相关的一个潜在的严重并发症的颅放射治疗，并应提高我们的理解正常大脑的耐受性颅照射后。
The tolerance of normal brain tissues limits the radiation dose than can be delivered safely during cranial radiotherapy, and one of the potential complications that can arise involves cognitive impairment. Extensive laboratory data have appeared recently showing that hippocampal neurogenesis is significantly impacted by irradiation and that such changes are associated with altered cognitive function and involves, in part, changes in the microenvironment (oxidative stress, inflammation). While there is considerable uncertainty about exactly how these changes evolve, new in vitro and in vivo approaches have provided a means by which new mechanistic insights can be gained relevant to the topic. Together, the data from cell culture and animal-based studies provide complementary information relevant to a potentially serious complication of cranial radiotherapy, and should enhance our understanding of the tolerance of normal brain after cranial irradiation.
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影响因子：
1.7
作者：
Limoli, C. L.;Giedzinski, E.;Fike, J. R.
通讯作者：
Fike, J. R.
影响因子：
2.6
作者：
Levin, ED;Brady, TC;Crapo, JD
通讯作者：
Crapo, JD
影响因子：
2.6
作者：
Limoli, Charles L.;Giedzinski, Erich;Fike, John R.
通讯作者：
Fike, John R.
DOI：
10.1111/j.1749-6632.1999.tb07820.x
发表时间：
1999-01-01
期刊：
OXIDATIVE/ENERGY METABOLISM IN NEURODEGENERATIVE DISORDERS
影响因子：
--
作者：
Huang, TT;Carlson, EJ;Epstein, CJ
通讯作者：
Epstein, CJ
影响因子：
3.4
作者：
Fan, Yang;Liu, Zhengyan;Liu, Jialing
通讯作者：
Liu, Jialing