Dll4, a novel Notch ligand expressed in arterial endothelium.
Dll4, a novel Notch ligand expressed in arterial endothelium.
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DOI：
10.1101/gad.14.11.1313
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发表时间：
2000-06
影响因子：
10.5
通讯作者：
J. Shutter;S. Scully;W. Fan;W. Richards;J. Kitajewski;G. Deblandre;C. Kintner;K. Stark
中科院分区：
文献类型：
--
作者：
J. Shutter;S. Scully;W. Fan;W. Richards;J. Kitajewski;G. Deblandre;C. Kintner;K. Stark
我们报告的克隆和表征的三角洲家庭的Notch配体，我们命名为Dll4的新成员。与其他Delta基因一样，Dll 4被预测编码膜结合配体，其特征在于含有几个EGF样结构域和受体结合所需的DSL结构域的胞外区。原位分析揭示了血管内皮内Dll4的高度选择性表达模式。Dll 4的活性和表达以及该家族其他成员的已知作用表明Dll 4在控制内皮细胞生物学中的作用。
We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.