Motor unit number estimation in infants and children with spinal muscular atrophy
Motor unit number estimation in infants and children with spinal muscular atrophy
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DOI：
10.1002/mus.10050
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发表时间：
2002-03-01
期刊：
影响因子：
3.4
通讯作者：
Swoboda, KJ
中科院分区：
文献类型：
--
作者：
Bromberg, MB;Swoboda, KJ
脊髓性肌萎缩症（SMA）是一种下部运动神经元的疾病。运动单元数估计（MUNE）是一种估计支配肌肉群的运动神经元数量的电生理学方法。我们应用多点刺激技术对尺神经-鱼际下肌群进行研究，研究了14例SMA患者（包括症状前患者，年龄从新生儿到45岁不等）较低的运动神经元损失。初步数据支持MUNE的价值，有助于了解SMA中运动神经元损失的时间过程。(C) 2002 Wiley期刊有限公司
Spinal muscular atrophy (SMA) is a disease of lower motor neurons. Motor unit number estimation (MUNE) is an electrophysiologic method to estimate the number of motor neurons innervating a muscle group. We applied the multiple point stimulation technique to the ulnar nerve-hypothenar muscle group to study lower motor neuron loss in 14 SMA subjects, including those presymptomatic, and varying from newborn through 45 years of age. Preliminary data support the value of MUNE to help understand the time course of motor neuron loss in SMA. (C) 2002 Wiley Periodicals, Inc.