Meta-analysis of immunohistochemical expression of hypoxia inducible factor-1α as a prognostic role in gastric cancer
Meta-analysis of immunohistochemical expression of hypoxia inducible factor-1α as a prognostic role in gastric cancer
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DOI：
10.3748/wjg.v20.i4.1107
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发表时间：
2014-01-28
影响因子：
4.3
通讯作者：
Cai, Xiu-Jun
中科院分区：
文献类型：
--
作者：
Lin, Shuang;Ma, Rui;Cai, Xiu-Jun
目的：进行荟萃分析，评估缺氧诱导因子 1 α (HIF-1 α) 表达在胃癌中的预后作用。方法：系统检索 PubMed、EMBASE 和 Web of Science 数据库，查找 2013 年 8 月之前发表的所有英文文章。根据现有数据计算汇总效应，以评估 HIF-1 α 表达与 5 年总生存率和肿瘤之间的关联 胃癌患者的临床病理特征。使用固定效应或随机效应模型计算 95% CI 的合并比值比 (OR)。 结果：9 项研究符合选择标准，报告了 1103 名受试者，其中 548 名受试者具有 HIF-1 α 阳性表达 (50%)。这项荟萃分析表明，胃癌中 HIF-1 α 阳性表达与较低的 5 年总生存率（OR = 0.36；95% CI：0.21-0.64）、较差的肿瘤分化（OR = 0.38；95% CI：0.23-0.64）、更深的侵袭（OR = 0.42；95% CI：0.32-0.57）、较高的淋巴结转移率相关。 淋巴结转移（OR = 2.23；95% CI：1.46-3.40）、淋巴管侵犯（OR = 2.50；95% CI：1.46-4.28）和血管侵犯（OR = 1.80；95% CI：1.29-2.51）和较高的 TNM 分期（III + IV）（OR = 0.31；95%） CI： 0.15-0.60）。结论：HIF-1α阳性表达提示胃癌患者预后不良。需要进一步的研究来证实这些结果。 (C) 2014 百事登出版集团有限公司。版权所有。
AIM: To conduct a meta-analysis to evaluate the prognostic role of hypoxia inducible factor-1 alpha (HIF-1 alpha) expression in gastric cancer.METHODS: The PubMed, EMBASE, and Web of Science databases were searched systematically for all articles published in English before August, 2013. Pooled effect was calculated from the available data to evaluate the association between HIF-1 alpha expression and 5-year overall survival and tumor clinicopathological features in gastric cancer patients. Pooled odds ratios (ORs) with 95% CIs were calculated using either a fixed-effects or a random-effects model.RESULTS: Nine studies matched the selection criteria, which reported on 1103 subjects, 548 of whom had HIF-1 alpha positive expression (50%). This meta-analysis indicated that HIF-1 alpha positive expression in gastric cancer correlated with lower 5-year overall survival (OR = 0.36; 95% CI: 0.21-0.64), worse tumor differentiation (OR = 0.38; 95% CI: 0.23-0.64), deeper invasion (OR = 0.42; 95% CI: 0.32-0.57), higher rates of lymph node metastasis (OR = 2.23; 95% CI: 1.46-3.40), lymphatic invasion (OR = 2.50; 95% CI: 1.46-4.28), and vascular invasion (OR = 1.80; 95% CI: 1.29-2.51), and higher TNM stage (III + IV) (OR = 0.31; 95% CI: 0.15-0.60).CONCLUSION: HIF-1 alpha positive expression indicates a poor prognosis for patients with gastric cancer. Further studies are required to confirm these results. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.