Accessing DNA damage in chromatin: insights from transcription
Accessing DNA damage in chromatin: insights from transcription
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DOI：
10.1002/(sici)1521-1878(199907)21:7
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发表时间：
1999-07-01
期刊：
影响因子：
4
通讯作者：
Smerdon, MJ
中科院分区：
文献类型：
--
作者：
Meijer, M;Smerdon, MJ
最近，研究 DNA 加工的领域出现了融合，例如转录、复制和修复。这种融合主要围绕染色质中 DNA 的包装。染色质结构影响 DNA 加工的各个方面，因为它调节蛋白质与 DNA 的接触。因此，一个中心主题已成为获取染色质中 DNA 的机制。这些过程之一涉及的机制似乎也可以用于其他过程。例如，具有组蛋白乙酰转移酶活性的转录共激活因子和染色质重塑复合物的发现为有效修复染色质中的DNA提供了可能的机制。 (C) 1999 约翰威利父子公司
Recently, there has been a convergence of fields studying the processing of DNA, such as transcription, replication, and repair. This convergence has been centered around the packaging of DNA in chromatin. Chromatin structure affects ail aspects of DNA processing because it modulates access of proteins to DNA. Therefore, a central theme has become the mechanism(s) for accessing DNA in chromatin. It seems likely that mechanisms involved in one of these processes may also be used in others. For example, the discovery of transcriptional coactivators with histone acetyltransferase activity and chromatin remodeling complexes has provided possible mechanisms required for efficient repair of DNA in chromatin. (C) 1999 John Wiley & Sons, Inc.