THE GASTRIC CARDIA IN HELICOBACTER-PYLORI INFECTION
THE GASTRIC CARDIA IN HELICOBACTER-PYLORI INFECTION
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DOI：
10.1016/0046-8177(94)90011-6
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发表时间：
1994-09-01
期刊：
影响因子：
3.3
通讯作者：
GRAHAM, DY
中科院分区：
文献类型：
--
作者：
GENTA, RM;HUBERMAN, RM;GRAHAM, DY
幽门螺杆菌胃炎被认为是更普遍和更严重的胃窦比身体。贲门的粘膜在结构上与胃窦的粘膜相似。本研究旨在检验幽门螺杆菌感染和相关炎症的强度在贲门和胃窦中相似，并且在这些位置比在胃体中更大的假设。从50例受试者（42例证实幽门螺杆菌感染）的预定部位共获得445份胃活检标本。用组合染色剂对载玻片进行染色，以同时观察幽门螺杆菌、粘膜形态和炎性浸润。幽门螺杆菌、炎症反应和肠上皮化生的数量按0 - 5级进行分级。在42例感染者中，有40例（95%）的贲门处检测到幽门螺杆菌。幽门螺杆菌密度在三个胃区域相似。胃窦和贲门的慢性活动性胃炎的强度相似，且高于胃体（P <0.005）。贲门和胃体中的类滤泡明显少于胃窦（P <0.05）。幽门螺杆菌感染在贲门和胃的其他部位一样普遍，其密度在胃窦、胃体和贲门的所有部位相似。慢性活动性胃炎的炎症反应特征，除了淋巴滤泡，在胃窦和贲门是相似的，在这两个位置比在身体更强烈。这些研究结果的意义进行了讨论与幽门螺杆菌感染和胃腺癌和淋巴瘤的发生之间的关系。《人文哲学》25：915-919。这是美国政府的工作。它的使用没有限制。
Helicobacter pylori gastritis is believed to be both more prevalent and more severe in the antrum than in the corpus. The mucosa of the cardia is architecturally similar to that of the antrum. This study was designed to test the hypothesis that intensity of H pylori infection and the associated inflammation are similar in the cardia and the antrum and are greater in these locations than in the corpus. A total of 445 gastric biopsy specimens were obtained from predetermined sites from 50 subjects (42 with demonstrated H pylori infection). Slides were stained with a combined stain to simultaneously visualize H pylori, mucosal morphology, and inflammatory infiltrate. Numbers of H pylori, inflammatory responses, and intestinal metaplasia were graded on a scale from 0 to 5. Helicobacter pylori was detected in the cardia of 40 of the 42 infected subjects (95%). Helicobacter pylori density was similar in the three gastric regions. The intensity of chronic active gastritis was similar in the antrum and the cardia, and was higher in these locations than in the corpus (P < .005). Lymphoid follicles were significantly less prevalent in the cardia and in the corpus than in the antrum (P < .05). Helicobacter pylori infection was as prevalent in the cardia as in the rest of the stomach and its density was similar in all sites of antrum, corpus, and cardia. The inflammatory responses characteristic of chronic active gastritis, except for lymphoid follicles, were similar in the antrum and the cardia and in both these locations were more intense than in the corpus. The significance of these findings is discussed with respect to the relationship between H pylori infection and the genesis of gastric adenocarcinoma and lymphoma. HUM PATHOL 25:915-919. This is a US government work. There are no restrictions on its use.