Peptide-based vesicles and droplets: a review
Peptide-based vesicles and droplets: a review
复制标题
基于肽的囊泡和液滴：综述
DOI：
10.1088/1361-648x/abb995
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Dutt, Meenakshi
中科院分区：
文献类型：
--
作者：
Mushnoori, Srinivas;Lu, Chien Y;Schmidt, Kassandra;Zang, Ethan;Dutt, Meenakshi
由于基于氨基酸的生物分子组装体的多功能性、可调节性和巨大的设计空间，肽组装是越来越重要的研究领域。肽可以被精确地工程化以具有各种有用的性质，例如形成超分子组装体的能力、对pH的期望响应或热稳定性。这些肽超分子组装体具有多种形态，包括囊泡、纳米管、纳米棒和带状物。特别令人感兴趣的是工程肽的领域，这些肽由于其封装特性而聚集成球形纳米结构：以可控方式保持，运输和释放化学有效载荷的能力。这对于纳米医学和靶向药物递送领域是非常宝贵的。在这篇综述中，最先进的肽为基础的囊泡和纳米球的领域进行了总结。具体地，提供了肽组装成纳米囊泡和纳米球的概述。芳香族以及脂肪族侧链氨基酸进行了讨论。芳香族侧链氨基酸残基的结构域主要由基于苯丙氨酸的肽及其变体主导。酪氨酸也表现出类似的聚集特性。实验和计算驱动的方法进行了讨论。基于脂族氨基酸残基的囊泡和液滴的结构域更宽，并且详述了多个氨基酸残基，例如丙氨酸、缬氨酸、赖氨酸、甘氨酸、脯氨酸和天冬氨酸。最后，讨论了潜在的未来方向。
Peptide assembly is an increasingly important field of study due to the versatility, tunability and vast design space of amino acid based biomolecular assemblies. Peptides can be precisely engineered to possess various useful properties such as the ability to form supramolecular assemblies, desired response to pH, or thermal stability. These peptide supramolecular assemblies have diverse morphologies including vesicles, nanotubes, nanorods and ribbons. Of specific interest is the domain of engineering peptides that aggregate into spherical nanostructures due to their encapsulation properties: the ability to hold, transport and release chemical payloads in a controllable manner. This is invaluable to the fields of nanomedicine and targeted drug delivery. In this review, the state of the art in the domain of peptide-based vesicles and nanospheres is summarized. Specifically, an overview of the assembly of peptides into nanovesicles and nanospheres is provided. Both aromatic as well as aliphatic side chain amino acids are discussed. The domain of aromatic side chained amino acid residues is largely dominated by phenylalanine based peptides and variants thereof. Tyrosine also demonstrates similar aggregation properties. Both experimentally and computationally driven approaches are discussed. The domain of aliphatic amino acid residues based vesicles and droplets is broader, and details multiple amino acid residues such as alanine, valine, lysine, glycine, proline, and aspartic acid. Finally, a discussion on potential future directions is provided.
登录
查看更多内容
三种含有酸性和碱性侧链的丙氨酸肽的酸碱特性：理论与实验的比较
影响因子：
2.9
作者：
J. Makowska;K. Bagińska;A. Liwo;L. Chmurzyński;H. Scheraga
通讯作者：
H. Scheraga
游泳课
影响因子：
64.8
作者：
A. Lamond
通讯作者：
A. Lamond
影响因子：
4.6
作者：
Huang, Yun-Chiao;Yang, Yao-Sheng;Jan, Jeng-Shiung
通讯作者：
Jan, Jeng-Shiung
β-丙氨酸同四聚体的自组装：形成用于药物输送的纳米囊泡。
DOI：
10.1039/c5tb00652j
发表时间：
2015
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
R. Goel;Swarita Gopal;Alka Gupta
通讯作者：
Alka Gupta
具有高迁移率 Group Box 1A 结构域的 R3V6 两亲性肽作为基因传递的有效载体
DOI：
--
发表时间：
2013
期刊：
影响因子：
--
作者：
J. Ryu;Pureum Jeon;Minhyung Lee
通讯作者：
Minhyung Lee