Signals and regulators that govern Streptomyces development.
Signals and regulators that govern Streptomyces development.
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DOI：
10.1111/j.1574-6976.2011.00317.x
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发表时间：
2012-01
影响因子：
11.3
通讯作者：
Flärdh K
中科院分区：
文献类型：
--
作者：
McCormick JR;Flärdh K
天蓝色链霉菌是属于革兰氏阳性放线菌的种群众多的属中遗传特征最好的物种。链霉菌是丝状土壤生物，以产生大量具有生物活性的次生代谢化合物而闻名。链霉菌的发育生命周期非常复杂，涉及协调的多细胞发育以及多种细胞类型的生理和形态分化，最终产生次级代谢产物和成熟孢子的扩散。这篇综述介绍了目前对用于协调形态分化决策的信号机制的认识，以及指导多基因组菌丝有趣发展的调节器和调节网络，首先形成专门的气生菌丝，然后将它们转化为休眠孢子链。当前对天蓝色链球菌发育的看法注定会快速进化，因为“组学”研究的数据揭示了基因调控网络，新的基因筛选识别出迄今为止未知的参与者，以及我们对潜在细胞生物过程的洞察力的分辨率稳步提高。
Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the Gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex, and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae, first to form specialized aerial hyphae, and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from “-omics” studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve.
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影响因子：
3.2
作者：
Ainsa, JA;Ryding, NJ;Chater, KF
通讯作者：
Chater, KF
DOI：
10.1099/00221287-144-6-1465
发表时间：
1998-06-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Chater, KF
通讯作者：
Chater, KF
影响因子：
3.2
作者：
Bibb, MJ;Molle, V;Buttner, MJ
通讯作者：
Buttner, MJ
影响因子：
3.6
作者：
Capstick, David S.;Willey, Joanne M.;Elliot, Marie A.
通讯作者：
Elliot, Marie A.
影响因子：
3.6
作者：
Beaucher, J;Rodrigue, S;Gaudreau, L
通讯作者：
Gaudreau, L