Budding invasive margin and prognosis in colorectal cancer -: no direct association with β-catenin expression
Budding invasive margin and prognosis in colorectal cancer -: no direct association with β-catenin expression
复制标题
DOI：
10.1016/j.ejca.2006.01.017
复制
发表时间：
2006-05-01
影响因子：
8.4
通讯作者：
Makinen, Markus J.
中科院分区：
文献类型：
--
作者：
Horkko, Tuomo T.;Klintrup, Kai;Makinen, Markus J.
直肠癌浸润性边缘的癌细胞萌发与预后不良有关。β-连环蛋白是一种黏附蛋白，参与核Wnt/β-连环蛋白途径和结直肠癌细胞间充质转化。因此，我们研究了浸润性边缘癌细胞萌发、β-连环蛋白表达与结直肠癌5年生存率之间的关系。对466例结直肠癌标本进行了萌芽切缘分析，并用免疫组织化学方法检测了同一组标本中β-连环素的表达。萌发切缘的出现率为24.0%，预测5年生存率较差(15.4%，P<；0.00001)。核β-连环蛋白的表达从中心区向侵袭性边缘增加(P<；0.001)，但不能预测萌芽。萌芽切缘是结直肠癌预后不良的独立因素，可用于诊断病理学。核β-连环蛋白经常在侵袭性边缘被发现，但不太可能是萌发的唯一原因。(C)2006爱思唯尔有限公司。保留所有权利。
Cancer cell budding at the invasive margin has been associated with poor prognosis in rectal cancer. beta-Catenin is an adhesion protein involved in the nuclear Wnt/beta-catenin pathway, and mesenchymal transition of colorectal cancer cells. Hence, we investigated the relationship between cancer cell budding at the invasive margin, beta-catenin expression, and 5-year-survival in colorectal cancer. Four hundred and sixty six colorectal cancer specimens were analysed for budding margin, and 108 specimens from the same set for beta-catenin by immunohistochemistry A budding margin was present in 24.0% of the cases and predicted a poor 5-year-survival (15.4%, P < 0.00001). Nuclear beta-catenin expression increased from the central area towards the invasive margin (P < 0.001), but did not predict budding. Budding margin is an independent factor associated with poor prognosis in colorectal cancer, and could be utilised in diagnostic pathology. Nuclear beta-catenin was often found at the invasive margin, but is unlikely to be the sole cause of budding. (c) 2006 Elsevier Ltd. All rights reserved.