The lipoxin biosynthetic circuit and their actions with human neutrophils.
The lipoxin biosynthetic circuit and their actions with human neutrophils.
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DOI：
10.1007/978-1-4684-6024-7_7
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发表时间：
1991
影响因子：
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通讯作者：
S. Fiore;M. Brezinski;K. Sheppard;C. Serhan
中科院分区：
文献类型：
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作者：
S. Fiore;M. Brezinski;K. Sheppard;C. Serhan
炎症细胞中的信号转导与脂氧合酶释放和氧化花生四烯酸有关（1，2）。脂氧素（LX）是最近添加到家庭的生物活性产品产生的花生四烯酸统称为类花生酸。LX系列的成员含有共轭四烯结构（3），并显示出独特的生物活性谱，使其区别于其他类二十烷酸（3，4）。沿着这些路线，最近几个实验室的结果（5-9）表明，LXA 4 ** 阻断了白三烯的一些“促炎”作用。综上所述，它们表明LX可能作为炎症反应中的一种查尔酮.因此，完全了解它们的生物合成、形成的时间关联以及与其他类花生酸的关系对于解开这些含四烯类花生酸在炎症以及其他生理事件中的功能是至关重要的。
Signal transduction in inflammatory cells is associated with the release and oxygenation of arachidonic acid by lipoxygenases (1, 2). The lipoxins (LX) are a recent addition to the family of biologically active products generated from arachidonic acid collectively termed eicosanoids. Members of the LX series contain a conjugated tetraene structure (3) and display a unique spectrum of bioactivities which distinguish them from other eicosanoids (3, 4). Along these lines, recent results from several laboratories (5–9) indicate that LXA4** blocks some of the “proinflammatory” actions of leukotrienes. Taken together they suggest that LX may serve aschalonesin inflammatory responses. Therefore, complete knowledge of their biosynthesis, temporal association of formation and relationship to other eicosanoids is essential to unraveling the functions of these tetraene-containing eicosanoids in inflammation as well as other physiologic events.