Enteral glutamine spares endogenous glutamine in chronic acidosis.
Enteral glutamine spares endogenous glutamine in chronic acidosis.
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肠内谷氨酰胺在慢性酸中毒时可以避免内源性谷氨酰胺。
DOI：
10.1177/0148607194018003243
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
S. Joshi
中科院分区：
文献类型：
--
作者：
T. Welbourne;S. Joshi
Metabolic acidosis associated with the catabolic state mobilizes muscle nitrogen and releases it into blood as glutamine (GLN) targeted for renal consumption and base generation. Because GLN removed by the kidneys during acidosis is a major drain on the GLN available to other sites, subsequent deprivation may lead to impaired organ function. Conversely, GLN supplementation may spare endogenous supplies and restore organ function. To test this, Sprague-Dawley rats weighing between 250 and 350 g were pair-fed elemental diets supplemented with GLN 4.9 g/L (GLN-ED) or an equivalent mixture of neutral amino acids substituted for GLN (ED). Acid loading was effected by adding hydrochloric acid to the liquid diet (110 mmol/L). Animals were studied in metabolic cages for five consecutive 24-hour urine collection periods and then anesthetized for short-term studies of interorgan fluxes and tissue GLN content. Acidosis effected an increase in ammonium nitrogen excretion (fivefold) and a reciprocal decrease (24%) in urea nitrogen excretion. Enteral GLN had no effect on the acidosis-effected ammonium (2170 +/- 71 vs 2059 +/- 361 mumol/100 g, ED vs GLN-ED, respectively) or urea excretion (5522 +/- 95 vs 5915 +/- 984 mumol/100 g, ED vs GLN-ED, respectively). Although arterial blood GLN was not increased in the GLN-ED group (531 +/- 58 vs 438 +/- 51 nmol/mL, p = .10), both liver and muscle GLN were elevated (11,650 +/- 1137 nmol/g vs 7063 +/- 578 and 5503 +/- 489 and 4742 +/- 333 nmol/g, respectively, each p < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
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糖皮质激素对肺谷氨酰胺和丙氨酸代谢的影响。
影响因子：
3.8
作者：
Souba,WW;Plumley,DA;Salloum,RM;Copeland3rd,EM
通讯作者：
Copeland3rd,EM
DOI：
10.1016/0022-4804(90)90244-v
发表时间：
1990-06
期刊：
The Journal of surgical research
影响因子：
--
作者：
R. Salloum;W. Souba;Alarico Fernandez;B. Stevens
通讯作者：
R. Salloum;W. Souba;Alarico Fernandez;B. Stevens
代谢性酸中毒对后躯谷氨酰胺和丙氨酸释放的影响。
DOI：
10.1016/0026-0495(86)90166-6
发表时间：
1986
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Welbourne,TC
通讯作者：
Welbourne,TC
谷氨酰胺酶、谷氨酸脱氢酶和 AMP 脱氨酶途径在肝尿素生成中的相对作用：15N 的研究。
影响因子：
3.9
作者：
Nissim,I;Cattano,C;Nissim,I;Yudkoff,M
通讯作者：
Yudkoff,M
酸中毒期间的器官间谷氨酰胺代谢。
DOI：
10.1177/014860719001400409
发表时间：
1990
期刊：
JPEN. Journal of parenteral and enteral nutrition
影响因子：
--
作者：
Welbourne,TC;Joshi,S
通讯作者：
Joshi,S