Comparative analysis of event-related potentials during Go/NoGo and CPT: Decomposition of electrophysiological markers of response inhibition and sustained attention
Comparative analysis of event-related potentials during Go/NoGo and CPT: Decomposition of electrophysiological markers of response inhibition and sustained attention
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DOI：
10.1016/j.brainres.2006.03.010
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发表时间：
2006-08-09
期刊：
影响因子：
2.9
通讯作者：
Demiralp, Tamer
中科院分区：
文献类型：
--
作者：
Kirmizi-Alsan, Elif;Bayraktaroglu, Zubeyir;Demiralp, Tamer
神经心理学测试针对特定的认知功能;然而，每个测试都涉及许多认知子组件。采用事件相关电位（ERPs）对24名被试的Go/NoGo（GNG）和CPT（cueed continuous performance task）两种额叶执行功能测试的成分进行了时域和时频分析。在时域中，测量P1、N1、P2、N2和P3后时间段的100 ins时间窗的峰值幅度和平均幅度。对于GNG，N1振幅以及GNG和CPT N2振幅在NoGo条件下显著高于Go条件。P3在两种范式的NoGo条件下都有一个中央最大值，而在Go条件下则有一个顶叶最大值。CPT中除P1外的所有峰和后P3期的平均振幅均比GNG中的峰更阳性。在CPT中，NoGo条件下的N1、N2和P3潜伏期长于Go条件下的N1、N2和P3潜伏期。在时间-频率分析中，NoGo条件诱发的θ系数高于Go条件，而CPT和GNG范式主要在δ波段不同。这些结果表明，θ成分反映了GNG和CPT的反应抑制，而δ成分反映了CPT更苛刻的持续注意要求。在CPT范式的NoGo条件下观察到的潜伏期延长被认为是由于CPT中的引物刺激增强了毅力/抑制冲突。(c)2006 Elsevier B. V.保留所有权利。
Neuropsychological tests target specific cognitive functions; however, numerous cognitive subcomponents are involved in each test. The aim of this study was to decompose the components of two frontal executive function tests, Go/NoGo (GNG) and cued continuous performance task (CPT), by analyzing event-related potentials (ERPs) of 24 subjects both in time and time-frequency domains. In the time domain, P1, N1, P2, N2 and P3 peak amplitudes and latencies and mean amplitudes of 100 ins time windows of the post-P3 time period were measured. For GNG, the N1 amplitude and for both GNG and CPT N2 amplitudes were significantly higher in the NoGo condition compared with the Go condition. P3 had a central maximum in the NoGo conditions of both paradigms in contrast to a parietal maximum in the Go conditions. All peaks except P1 and mean amplitudes of the post-P3 period were more positive in CPT compared to those of GNG. N1, N2 and P3 latencies were longer for the NoGo condition than the Go condition in the CPT. In time-frequency analyses, the NoGo condition evoked higher theta coefficients than the Go condition, whereas the CPT and GNG paradigms differed mainly in the delta band. These results suggest that theta component reflects response inhibition in both GNG and CPT, whereas delta component reflects the more demanding sustained attention requirement of the CPT. The latency prolongation observed with the NoGo condition of the CPT paradigm was thought to be due to perseverance/inhibition conflict enhanced by the primer stimuli in CPT. (c) 2006 Elsevier B.V. All rights reserved.