Imaging Auditory Representations of Song and Syllables in Populations of Sensorimotor Neurons Essential to Vocal Communication
Imaging Auditory Representations of Song and Syllables in Populations of Sensorimotor Neurons Essential to Vocal Communication
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DOI：
10.1523/jneurosci.2308-14.2015
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发表时间：
2015-04-08
影响因子：
5.3
通讯作者：
Mooney, Richard
中科院分区：
文献类型：
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作者：
Peh, Wendy Y. X.;Roberts, Todd F.;Mooney, Richard
声音交流依赖于感觉运动神经元的协调活动，这些神经元对声音的感知和产生至关重要。在这些神经元群体中，发声如何由时空活动模式表示仍然知之甚少。在这里，我们结合细胞内记录和双光子钙成像在麻醉成年斑胸草雀（Taeniopygia guttata），研究如何学习鸟鸣和其组成音节表示在确定的投射神经元（PN）内HVC，感觉运动区重要的歌曲感知和生产。这些实验表明，相邻的HVC PN可以响应在显着不同的时间播放歌曲，不同的音节激活空间混合PN内的本地（类似于100 μ m）区域的HVC。此外，噪声的相关性更强的PN之间的反应最强烈的同一音节，并在空间上分级内和类之间的PN。这些研究结果支持一个模型，在该模型中，音节和时间特征的歌曲表示的空间混合PN功能组织成细胞和音节类型的网络在本地的空间尺度在HVC。
Vocal communication depends on the coordinated activity of sensorimotor neurons important to vocal perception and production. How vocalizations are represented by spatiotemporal activity patterns in these neuronal populations remains poorly understood. Here we combined intracellular recordings and two-photon calcium imaging in anesthetized adult zebra finches (Taeniopygia guttata) to examine how learned birdsong and its component syllables are represented in identified projection neurons (PNs) within HVC, a sensorimotor region important for song perception and production. These experiments show that neighboring HVC PNs can respond at markedly different times to song playback and that different syllables activate spatially intermingled PNs within a local (similar to 100 mu m) region of HVC. Moreover, noise correlations were stronger between PNs that responded most strongly to the same syllable and were spatially graded within and between classes of PNs. These findings support a model in which syllabic and temporal features of song are represented by spatially intermingled PNs functionally organized into cell- and syllable-type networks within local spatial scales in HVC.