CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma
CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma
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DOI：
10.1016/s0304-3835(01)00846-1
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发表时间：
2002-05-08
期刊：
影响因子：
9.7
通讯作者：
Liu, ZH
中科院分区：
文献类型：
--
作者：
Wang, Q;Lu, JY;Liu, ZH
抑制性消减杂交显示钙/钙调蛋白依赖性丝氨酸蛋白激酶(CAASK)在人食管癌组织中过表达。采用逆转录-聚合酶链式反应(RT-PCR)、免疫组织化学及Western印迹等方法检测了人食道癌组织中木桶痤疮及其靶基因Reelin的表达。RT-PCR结果表明，CASK和Reelin在人胃癌和结肠癌中的表达模式不同于食道癌。因此，我们认为CASK和REELIN与食道癌的发生有关，并且在食道癌中共同上调。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Calcium/calmodulin-dependent serine protein kinase (CASK) showed overexpression in human esophageal carcinoma by suppression subtractive hybridization. The upregulation of CASK acne and its target gene Reelin in human esophageal carcinoma tissues versus corresponding normal tissues was revealed by reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry or Western blot. Moreover, RT-PCR results indicated that the expression patterns of CASK and Reelin in human gastric carcinoma and colon carcinoma were different with those in esophaggeal carcinoma. Therefore, it suggested that CASK and Reelin were associated with tumorigenesis of esophagus and they were co-upregulated in human esophageal carcinoma. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.