Telomere heterogeneity: taking advantage of stochastic events.
Telomere heterogeneity: taking advantage of stochastic events.
复制标题
端粒异质性：利用随机事件。
DOI：
10.1016/j.febslet.2009.02.032
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发表时间：
2009
期刊：
影响因子：
3.5
通讯作者：
Nosek,Jozef
中科院分区：
文献类型：
--
作者：
Tomaska,Lubomir;Nosek,Jozef
用来解决与线性DNA染色体末端(端粒)相关的问题的各种方法都有一个共同的特征：在结构和功能状态的水平上产生端粒的细胞内和细胞间异质性。我们认为，这种异质性并不是调节端粒维持的分子途径的简单副产品。相反，我们认为选择这些机制是因为它们产生了异质性。与基因表达中的噪音类似，端粒上的随机事件可能具有适应性价值，使细胞能够维持活的和灵活的种群，这对从进化生物学到分子医学等领域都有影响。
Various means employed to solve problems associated with the ends (telomeres) of linear DNA chromosomes exhibit one common feature: generation of both intra- and intercellular heterogeneity of telomeres at the level of their structural and functional states. We argue that this heterogeneity is not a simple by-product of molecular pathways mediating telomere maintenance. Instead, we propose that these mechanisms were selected because they generate heterogeneity. Similarly as noise in gene expression, stochastic events at telomeres may have an adaptive value allowing cells to sustain viable and flexible populations, with implications for fields ranging from evolutionary biology to molecular medicine.