Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function.
Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function.
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DOI：
10.4161/cib.19400
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发表时间：
2012-05-01
影响因子：
--
通讯作者：
Anderson HL
中科院分区：
文献类型：
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作者：
Reeve JE;Kohl MM;Rodríguez-Moreno A;Paulsen O;Anderson HL
我们之前已经合成了一种笼型的NMDA受体离子通道阻滞剂MK801，并使用该化合物的细胞内光解来证明参与突触可塑性的NMDA受体离子通道的亚细胞位置。在这里，我们讨论了笼状离子通道阻滞剂在神经生理学中的选择、合成和潜在用途。
We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology.