MATERNAL DISEASES AND RISK OF ISOLATED EAR ABNORMALITIES IN THEIR CHILDREN
MATERNAL DISEASES AND RISK OF ISOLATED EAR ABNORMALITIES IN THEIR CHILDREN
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DOI：
10.21101/cejph.a3676
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发表时间：
2011-09-01
影响因子：
1.2
通讯作者：
Banhidy, Ferenc
中科院分区：
文献类型：
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作者：
Paput, Laszlo;Czeizel, Andrew E.;Banhidy, Ferenc
该研究的目的是估计母亲疾病与孤立性耳部先天性异常（IECA）风险的可能关联，主要包括其子女的小耳畸形和厌食症。在匈牙利先天性异常病例对照监测的基于人群的大型数据集中，比较了IECA母亲及其匹配对照和所有无任何缺陷对照的母亲，以及具有其他孤立缺陷的畸形对照母亲的急性和慢性产妇疾病发病率和流行率。在354例IECA病例中，32例在IECA的关键时期母亲患有高热相关的流感-普通感冒，这导致其活产婴儿患IECA的风险高于对照组（校正OR 95% Cl: 4.3, 1.9-7.4）。然而，这些孕妇早期有效的退烧治疗阻止了她们发生IECA。此外，母体中耳炎与中耳和外耳复杂缺陷的高风险相关（OR 95% Cl: 5.2, 1.6-28.3），然而，这种关联仅基于4例。综上所述，高热相关的流感-普通感冒伴继发性并发症可能在IECA的发病中起作用，但对这些孕妇进行早期有效的退烧治疗是可以预防的。
The objective of the study was to estimate the possible association of maternal diseases with the risk of isolated ear congenital abnormalities (IECA) including mainly microtia and anotia in their children. Incidence of acute and prevalence of chronic maternal diseases in the mothers with IECA and in the mothers of their matched controls and all controls without any defects, in addition in the mothers of malformed controls with other isolated defects was compared in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities. Of 354 cases with IECA, 32 had mothers with high fever related influenza-common cold during the critical period of IECA and it resulted in a higher risk of IECA in their live-born infants (adjusted OR with 95% Cl: 4.3, 1.9-7.4) compared with their matched controls. However, the early and effective antifever treatment in these pregnant women prevented them from the IECA. In addition there was an association of maternal otitis media with higher risk of complex defects of middle and external ears (OR with 95% Cl: 5.2, 1.6-28.3), however, this association was based on 4 cases only. In conclusion high fever related influenza-common cold with secondary complications may play a role in the origin of IECA, but is preventable with the early and effective antifever treatment of these pregnant women.