Effect of γ-aminobutyric acid-rich yogurt on insulin sensitivity in a mouse model of type 2 diabetes mellitus
Effect of γ-aminobutyric acid-rich yogurt on insulin sensitivity in a mouse model of type 2 diabetes mellitus
复制标题
富含γ-氨基丁酸的酸奶对2型糖尿病小鼠模型胰岛素敏感性的影响
DOI：
10.3168/jds.2019-17757
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发表时间：
2020-09-01
影响因子：
3.5
通讯作者：
Lu, Yingjian
中科院分区：
文献类型：
--
作者：
Li, Xiangfei;Chen, Lin;Lu, Yingjian
本研究旨在探讨富含γ-氨基丁酸（GABA）的嗜热链球菌fmb-5发酵酸奶对高脂低剂量链脲佐菌素诱导的2型糖尿病小鼠胰岛素敏感性的影响。为了研究酸奶增强胰岛素敏感性的能力，糖尿病小鼠从第1周到第12周每天一次用0.5、1或2 g/L的GABA酸奶治疗。与未治疗的糖尿病小鼠的结果相比，用不同剂量的GABA酸奶治疗与血清胰岛素和脂肪系数（脂肪重量相对于体重）水平增加，血尿素氮，肾脏系数（肾脏重量相对于体重），葡萄糖曲线下面积水平和胰岛素敏感性指数降低有关，但不改变血糖水平或体重。最高剂量的GABA酸奶对胰岛素抵抗的有益效果比较低剂量的更大。特别是，饮食补充高剂量的GABA酸奶有利地调节HOMA-β（β细胞功能的稳态模型评估），总胆固醇，高密度脂蛋白胆固醇，脂肪系数，并改善胰岛细胞形态。结果表明，2g/L GABA酸奶可改善胰岛素敏感性。富含GABA的酸奶似乎对糖尿病小鼠模型的健康有益。
This study aimed to investigate the effect of a gamma-aminobutyric acid (GABA)-rich yogurt fermented with Streptococcus thermophilus fmb-5 on insulin sensitivity in high-fat and low-dose streptozotocin-induced type 2 diabetes mellitus mice. To study the ability of the yogurt to enhance insulin sensitivity, diabetic mice were treated with 0.5, 1, or 2 g/L of GABA yogurt once a day from wk 1 to 12. Compared with results in untreated diabetic mice, treatment with different dosages of GABA yogurt was associated with increased serum insulin and fat coefficient (fat weight relative to body weight) levels, decreased blood urea nitrogen, kidney coefficient (kidney weight relative to body weight), glucose area under the curve levels, and insulin sensitivity index, but did not alter blood glucose level or body weight. The highest dosage of GABA yogurt had a greater beneficial effect with respect to insulin resistance than the lower dosages. In particular, dietary supplementation of the high dosage of GABA yogurt favorably regulated HOMA-beta (homeostasis model assessment of beta-cell function), total cholesterol, high-density lipoprotein cholesterol, fat coefficient, and improved islet cells morphology. These results demonstrated that 2 g/L GABA yogurt could ameliorate insulin sensitivity. The GABA-rich yogurts appeared to be responsible for health-beneficial effects in this mouse model of diabetes.