Flexible information routing by transient synchrony
Flexible information routing by transient synchrony
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DOI：
10.1038/nn.4569
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发表时间：
2017-07-01
影响因子：
25
通讯作者：
Battaglia, Demian
中科院分区：
文献类型：
--
作者：
Palmigiano, Agostina;Geisel, Theo;Battaglia, Demian
感知、认知和行为依赖于不同皮层区域微电路之间的灵活通信。这种微电路之间的快速信息重新路由的机制仍然是未知的。已经提出，改变局部伽马节律之间的相干性模式支持灵活的信息重新路由。然而，体内伽马振荡的随机性和瞬时性很难与这样的函数相协调。在这里，我们表明，振荡同步的发病附近的皮质电路的模型选择性路由输入信号，尽管伽马脉冲串的持续时间短，神经元放电的不规则性。在规范的多区域电路中，我们发现伽玛突发自发地出现匹配的时间和频率，他们组织信息流的大规模路由状态。特定的自组织路由状态可以通过对背景活动的轻微调制来诱导。
Perception, cognition and behavior rely on flexible communication between microcircuits in distinct cortical regions. The mechanisms underlying rapid information rerouting between such microcircuits are still unknown. It has been proposed that changing patterns of coherence between local gamma rhythms support flexible information rerouting. The stochastic and transient nature of gamma oscillations in vivo, however, is hard to reconcile with such a function. Here we show that models of cortical circuits near the onset of oscillatory synchrony selectively route input signals despite the short duration of gamma bursts and the irregularity of neuronal firing. In canonical multiarea circuits, we find that gamma bursts spontaneously arise with matched timing and frequency and that they organize information flow by large-scale routing states. Specific self-organized routing states can be induced by minor modulations of background activity.