Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans
Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans
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DOI：
10.1093/ajcn/68.6.1187
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发表时间：
1998-12-01
影响因子：
7.1
通讯作者：
Clevidence, BA
中科院分区：
文献类型：
--
作者：
Paetau, I;Khachik, F;Clevidence, BA
采用随机交叉设计，研究了番茄汁和两种膳食补充剂中的番茄红素在15名健康志愿者中的生物利用度，每个补充剂含有70-75 mg番茄红素。受试者摄入富含番茄红素的番茄汁、番茄油树脂、番茄红素珠粒和安慰剂，每次4wk，同时食用自己选择的饮食。治疗周期由6周冲洗期隔开。在整个治疗期间，在基线和每周评估的血浆番茄红素浓度，摄入番茄汁、油树脂和番茄红素微珠的患者显著高于服用安慰剂的患者。番茄汁、油树脂和番茄红素微珠摄入后第4周血浆番茄红素的平均(+/-)升高无显著差异：分别为0.24±0.07、0.23+/-0.05和0.24+/-0.06Mol/L。在番茄汁、油树脂和番茄红素小珠中少量存在的植氟烯和植烯的血浆浓度，随着这三种产品的摄入而显著增加。同样存在于番茄汁和补充剂中的β-胡萝卜素、Zeta-胡萝卜素和2，6-环糊精-1，5-二醇--也存在于番茄汁和补充剂中--随着番茄汁和番茄红素颗粒的摄入而显著增加，但与油树脂的消耗无关。观察到一种未知化合物的血浆浓度显著增加；在番茄汁、油树脂和番茄红素小球中检测到微量的未知化合物，其最大吸收波长为448 nm，相对分子质量为556。通过摄入适量的番茄汁，可以提高血浆中番茄红素和其他可能增强人体健康的类胡萝卜素的浓度。番茄红素似乎可以从番茄汁和本研究中使用的补充剂中获得同等的生物利用率。
The bioavailability of lycopene from tomato juice and 2 dietary supplements, each containing 70-75 mg lycopene, was studied in 15 healthy volunteers in a randomized, crossover design. Subjects ingested lycopene-rich tomato juice, tomato oleoresin, lycopene beadlets, and a placebo for 4 wk each while consuming self-selected diets. Treatment periods were separated by 6-wk washout periods. Plasma lycopene concentrations, assessed at baseline and weekly throughout the treatment periods, were significantly higher during tomato juice, oleoresin, and lycopene beadlet ingestion than during placebo ingestion. Mean (+/-SEM) increases in plasma lycopene at week 4 of tomato juice, oleoresin, and lycopene beadlet ingestion were not significantly different: 0.24 +0.07, 0.23 +/- 0.05, and 0.24 +/- 0.06 mu mol/L, respectively. Plasma concentrations of phytofluene and phytoene, which were present in small amounts in tomato juice, oleoresin, and lycopene beadlets, increased significantly with ingestion of these 3 products. beta-Carotene, zeta-carotene, and 2,6-cyclolycopene-1,5-diol (a metabolite of lycopene)-also present in tomato juice and supplements-were significantly increased with consumption of the tomato juice and lycopene beadlets, but not with oleoresin consumption. A marked increase in plasma concentrations of an unknown compound was observed; it was detected in trace amounts in tomato juice, oleoresin, and lycopene beadlets, and had a maximum absorbance at 448 nm and a molecular weight of 556. Concentrations of plasma lycopene and other carotenoids with potential for enhancing human health can be increased by ingestion of realistic amounts of tomato juice. Lycopene appears to be equally bioavailable from tomato juice and the supplements used in this study.