Antiphase oscillation of the left and right suprachiasmatic nuclei
Antiphase oscillation of the left and right suprachiasmatic nuclei
复制标题
DOI：
10.1126/science.290.5492.799
复制
发表时间：
2000-10-27
期刊：
影响因子：
56.9
通讯作者：
Schwartz, WJ
中科院分区：
文献类型：
--
作者：
de la Iglesia, HO;Meyer, J;Schwartz, WJ
动物的昼夜节律计时系统的一个不寻常的特性是节奏“分裂”，其中一个单一的日常身体活动（通常测量为车轮运行）分解为两个稳定耦合的组件，间隔约12小时;这种行为被归因于由两个反相循环的昼夜节律振荡器组成的时钟。我们分析了下丘脑昼夜节律钟，视交叉上核（SCN），行为“分裂”仓鼠住在恒定的光基因表达。结果表明，分裂条件下的两个振子对应于双边成对SCN的左右两侧。
An unusual property of the circadian timekeeping systems of animals is rhythm "splitting," in which a single daily period of physical activity (usually measured as wheel running) dissociates into two stably coupled components about 12 hours apart; this behavior has been ascribed to a clock composed of two circadian oscillators cycling in antiphase. We analyzed gene expression in the hypothalamic circadian clock, the suprachiasmatic nucleus (SCN), of behaviorally "split" hamsters housed in constant Light. The results show that the two oscillators underlying the split condition correspond to the Left and right sides of the bilaterally paired SCN.