Apoptosis in the treatment of cancer: a promise kept?
Apoptosis in the treatment of cancer: a promise kept?
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DOI：
10.1016/j.ceb.2006.10.008
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发表时间：
2006-12-01
影响因子：
7.5
通讯作者：
Kaufmann, Scott H.
中科院分区：
文献类型：
--
作者：
Meng, Xue Wei;Lee, Sun-Hee;Kaufmann, Scott H.
癌细胞的一个共同特征是，由于阻断细胞死亡信号通路的改变，它们能够逃避细胞凋亡。过去十年中阐明这些信号通路的广泛研究工作为开发选择性杀死癌细胞或重置其凋亡阈值的治疗药物奠定了基础。在过去两年中，许多此类药物已在临床前和临床试验中进行了评估。这些研究的结果表明，调节癌细胞的凋亡以获得治疗效果可能很快就会成为可能。
A common feature of cancer cells is their ability to evade apoptosis as a result of alterations that block cell death signaling pathways. The extensive research efforts that elucidated these signaling pathways over the past decade have set the stage for the development of therapeutic agents that either kill cancer cells selectively or reset their apoptotic threshold. Over the past two years a number of these agents have been evaluated in preclinical and clinical trials. The results of these studies suggest that it might soon be possible to modulate apoptosis in cancer cells for therapeutic benefit.