Acute anti body-mediated rejection of cardiac transplants
Acute anti body-mediated rejection of cardiac transplants
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DOI：
10.1016/j.healun.2005.09.003
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发表时间：
2006-02-01
影响因子：
8.9
通讯作者：
Fishbein, MC
中科院分区：
文献类型：
--
作者：
Reed, EF;Demetris, AJ;Fishbein, MC
在国际心肺移植学会的指导下，2004年对心脏活检分级系统进行了多学科审查，特别工作组检查了排斥反应的组织病理学、临床问题和研究领域。免疫病理学工作组小组委员会提出的一个重要的新领域是抗体介导的排斥反应的临床和诊断标准。这篇文章是一个伴侣文件的修订工作制定标准化的心脏排斥反应的诊断和审查已发表的文献，记录血清学和形态学证据，抗体介导的排斥反应是临床上显着的，并与移植物丢失，加速移植相关的冠状动脉疾病和死亡。本文还提供了一个更深入的分析抗体介导的排斥反应的免疫病理学工作组的修订1990年工作制定的标准化的心脏排斥反应的诊断术语。
Under the direction of the International Society for Heart and Lung Transplantation, a multidisciplinary review of the cardiac biopsy grading system was undertaken in 2004, with task forces examining the areas of histopathology of rejection, clinical issues, and research. An important new area addressed by the Immunopathology Task Force sub-committee was the clinical and diagnostic criteria for antibody-mediated rejection. This article is a companion paper to the revised working formulation for the standardization of nomenclature in the diagnosis of heart rejection and reviews the published literature documenting the serologic and morphologic evidence that antibody-mediated rejection is clinically significant and associated with graft loss, accelerated transplant-associated coronary artery disease, and death. This article also provides a more in-depth analysis of antibody-mediated rejection developed by the Immunopathology Task Force for revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection.