Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in rats
Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in rats
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DOI：
10.1111/j.1460-9568.2006.05193.x
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发表时间：
2006-12-01
影响因子：
3.4
通讯作者：
Kantak, Kathleen M.
中科院分区：
文献类型：
--
作者：
Di Pietro, Nina C.;Black, Yolanda D.;Kantak, Kathleen M.
前额叶皮层（PFC）内的刺激属性特异性的证据表明，不同的前额叶亚区可能有助于可卡因成瘾的功能不同的方式。因此，本研究探讨了利多卡因诱导的两个不同的PFC亚区，前边缘（PL）或背侧无颗粒岛（Ald）皮质失活的影响，在可卡因的维持和恢复测试条件下，在训练大鼠自我管理1毫克/公斤可卡因的二阶时间表下的药物输送的药物寻求和吸毒行为。在整个维持和恢复阶段，大鼠暴露于条件光线索和上下文气味或声音线索。结果表明，PL失活在维护测试期间显着减少药物寻求和吸毒行为，并打乱了大鼠暴露于光声，但不是光气味，线索的反应模式。此外，利多卡因诱导的失活PL显着衰减药物寻求行为的线索诱导和可卡因引发的恢复暴露于光-声线索只。相比之下，Ald失活显着衰减线索诱导的恢复药物寻求行为暴露于光气味线索只。无论使用何种类型的上下文线索，在维持和可卡因引发诱导的恢复测试期间，这些大鼠的寻药和吸毒行为都没有被破坏。总之，这些数据表明，PL和Ald次区域发挥独立但重叠的作用，在调节可卡因成瘾大鼠的方式是依赖于可卡因的存在或不存在和可卡因自我管理环境中存在的上下文线索的类型。
Evidence of stimulus attribute-specificity within the prefrontal cortex (PFC) suggests that different prefrontal subregions may contribute to cocaine addiction in functionally distinct ways. Thus, the present study examined the effects of lidocaine-induced inactivation of two distinct PFC subregions, the prelimbic (PL) or dorsal agranular insular (Ald) cortices, on drug-seeking and drug-taking behaviors under cocaine maintenance and reinstatement testing conditions in rats trained to self-administer 1 mg/kg cocaine under a second-order schedule of drug delivery. Throughout maintenance and reinstatement phases, rats were exposed to conditioned light cues and contextual odor or sound cues. Results showed that PL inactivation during maintenance test sessions significantly reduced drug-seeking and drug-taking behaviors, and disrupted patterns of responding in rats exposed to light-sound, but not light-odor, cues. Moreover, lidocaine-induced inactivation of the PL significantly attenuated drug-seeking behavior during cue-induced and cocaine prime-induced reinstatement in rats exposed to light-sound cues only. In contrast, Ald inactivation significantly attenuated cue-induced reinstatement of drug-seeking behavior in rats exposed to light-odor cues only. Drug-seeking and drug-taking behaviors in these rats were not disrupted during maintenance and cocaine prime-induced reinstatement testing regardless of the type of contextual cues used. Together, these data suggest that PL and Ald subregions play separate yet overlapping roles in regulating cocaine addiction in rats in ways that are dependent on the presence or absence of cocaine and on the types of contextual cues present in the cocaine self-administration environment.