Optimizing the facility location design of organ transplant centers
Optimizing the facility location design of organ transplant centers
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DOI：
10.1016/j.dss.2012.05.059
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发表时间：
2013-03-01
影响因子：
7.5
通讯作者：
Van den Bossche, Filip
中科院分区：
文献类型：
--
作者：
Belien, Jeroen;De Boeck, Liesje;Van den Bossche, Filip
本文提出了一种混合整数线性规划（MILP）长期决策模型来优化器官移植中心的选址。目标是最小化供体器官可用的时刻和移植到受体体内的时刻之间的加权时间分量的总和。器官从供体摘除之前经过的时间的权重因子允许为目标函数中的该时间分量分配较低的权重，以反映器官摘除后过程的关键性。器官移植的特殊性使得该模型比传统的设施选址模型更加复杂。该模型应用于比利时器官移植路径。大量的数值实验揭示了影响集中移植中心与分散移植中心长期决策的关键因素。 (c) 2012 Elsevier B.V. 保留所有权利。
This paper presents a mixed integer linear programming (MILP) long-term decision model to optimize the location of organ transplant centers. The objective is to minimize the sum of the weighted time components between the moment a donor organ becomes available and its transplantation into the recipient's body. The weight factor for the elapsed time before the organ's removal from the donor body allows to assign a lower weight to this time component in the objective function in order to reflect the criticality of the process after the organ's removal. The specificity of organ transplants makes the model more complex than a traditional facility location model. The model is applied to the Belgian organ transplant path. Extensive numerical experiments reveal the key factors that impact the long-term decision of centralizing versus decentralizing transplant centers. (c) 2012 Elsevier B.V. All rights reserved.