FGF19 AND CANCER
FGF19 AND CANCER
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DOI：
10.1007/978-1-4614-0887-1_12
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Desnoyers, Luc R.
中科院分区：
文献类型：
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作者：
Lin, Benjamin C.;Desnoyers, Luc R.
成纤维细胞生长因子（FGF）及其同源受体FGF受体（FGFR）在多种正常发育和生理过程中起关键作用。许多报道支持FGF-FGFR信号传导的失调在肿瘤发展和进展中的作用，无论是在配体和/或受体水平。FGF 19-FGFR 4信号传导轴与几种癌症的发病机制有关，包括小鼠和潜在人类的肝细胞癌。本章重点介绍了FGF 19作用的分子机制及其在癌症中的潜在参与的最新进展。
Fibroblast growth factors (FGFs) and their cognate receptors, FGF receptors (FGFRs), play critical roles in a variety of normal developmental and physiological processes. Numerous reports support a role for deregulation of FGF-FGFR signaling, whether it is at the ligand and/or receptor level, in tumor development and progression. The FGF19-FGFR4 signaling axis has been implicated in the pathogenesis of several cancers, including hepatocellular carcinomas in mice and potentially in humans. This chapter focuses on recent progress in the understanding of the molecular mechanisms of FGF19 action and its potential involvement in cancer.