Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake).
Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake).
复制标题
从灰树花（舞茸）中获得的 β-葡聚糖可增强小鼠体内宿主介导的抗肿瘤活性。
DOI：
10.1248/cpb.35.262
复制
发表时间：
1987
影响因子：
1.7
通讯作者：
H. Kuroda
中科院分区：
文献类型：
--
作者：
Kyoko Adachi;H. Nanba;H. Kuroda
从灰树花（Grifola frondosa，maitake）子实体中提取的一种多糖（3-支链葡聚糖-1，6-葡聚糖MT-2）对小鼠同系肿瘤（MM-46癌和IMC癌）具有抗肿瘤作用。它不仅直接激活各种效应细胞（巨噬细胞，自然杀伤细胞，杀伤T细胞等），攻击肿瘤细胞，而且还增强包括淋巴因子和白细胞介素-1在内的各种介质的活性。因此，它起到增强细胞功能的作用，同时防止荷瘤宿主的免疫功能降低。
A polysaccharide (3-branched ƒÀ-1, 6-glucan MT-2) extracted from fruit bodies of Grifola frondosa (maitake) showed an antitumor effect against mouse syngeneic tumors (MM-46 carcinoma and IMC-carcinoma). It is not only directly activates various effector cells (macrophages, natural killer cells, killer T cells, etc.) to attack tumor cells, but also potentiates the activities of various mediators including lymphokines and interleukin-1. Thus, it acts to potentiate cellular functions and at the same time to prevent a decrease of immune functions of the tumor-bearing host.