Data quality evaluation of toxicological studies used to derive ecotoxicological benchmarks
Data quality evaluation of toxicological studies used to derive ecotoxicological benchmarks
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DOI：
10.1080/10807030091124176
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发表时间：
2000-10-01
影响因子：
4.3
通讯作者：
Preziosi, DV
中科院分区：
文献类型：
--
作者：
Durda, JL;Preziosi, DV
生态毒理学基准广泛用于生态风险评估，以确定环境中存在或可能释放到环境中的化学品是否构成生态威胁。目前还没有一致的标准来评价用于得出生态毒理学基准以供风险评估的毒理学研究的数据质量。本文概述了一个两阶段的方法来评估生态毒理学数据的质量，用于基准的发展。首先，毒理学研究进行审查，以确定其遵守一套标准化的毒理学测试和报告协议。第二，一旦根据对方案的遵守对研究进行了表征，则根据这些方案的应用程度分配质量描述符。该数据质量描述符可用于确定生态毒理学数据对基准开发的适用性，并描述任何基准的数据质量。作为一个测试案例，我们将这种两阶段的方法应用于生态风险评估中常用的一些基准。人们希望，使用这种方法将导致更好地了解用于生态风险评估的生态毒理学基准的优势和局限性，并最终支持更明智的风险管理决策。
Ecotoxicological benchmarks are used extensively in ecological risk assessment to determine if chemicals present in or potentially released to the environment pose an ecological threat. No consistent standards currently exist for data quality evaluation of toxicological studies used to derive ecotoxicological benchmarks for use in risk assessment. This paper outlines a two-phased approach for evaluating the quality of ecotoxicological data to be used in benchmark development. First, toxicological studies are reviewed to determine their adherence to a set of standardized toxicological testing and reporting protocols. Second, once the studies have been characterized according to adherence to the protocols, a quality descriptor is assigned based on the degree to which these protocols were applied. This data quality descriptor can be used to define the suitability of ecotoxicological data for benchmark development and to characterize the data quality of any resultant benchmark. As a test case, we apply this two-phased approach to some benchmarks commonly used in ecological risk assessment. It is hoped that use of this approach will lead to a greater understanding of the strengths and limitations of ecotoxicological benchmarks for use in ecological risk assessment and ultimately support more informed risk management decisions.