THE INFLUENCE OF PRIOR SYNAPTIC ACTIVITY ON THE INDUCTION OF LONG-TERM POTENTIATION
THE INFLUENCE OF PRIOR SYNAPTIC ACTIVITY ON THE INDUCTION OF LONG-TERM POTENTIATION
复制标题
DOI：
10.1126/science.1346729
复制
发表时间：
1992-02-07
期刊：
影响因子：
56.9
通讯作者：
MALENKA, RC
中科院分区：
文献类型：
--
作者：
HUANG, YY;COLINO, A;MALENKA, RC
长时程增强（LTP）是一个被广泛研究的突触可塑性模型，部分原因是它是一个合理的生物学相关的赫布突触修饰，形成神经发育，学习和记忆的理论模型的基础。虽然这些模型必须结合约束突触权重变化的算法，但这种机制的生理学证据是有限的。海马CA 1区的LTP检测显示，LTP诱导的阈值并不固定，但可能受到突触活动近期历史的强烈影响。这种效应是短暂的，突触特异性的，并依赖于突触后N-甲基-D-天冬氨酸（NMDA）受体激活。这些结果表明，LTP诱导的阈值可能会不断调整，根据最近的历史NMDA受体激活，并提供了一个生理机制，LTP可以被短暂抑制。
Long-term potentiation (LTP) is an extensively studied model of synaptic plasticity, in part because it is a plausible biological correlate for the Hebbian synaptic modification that forms the basis for theoretical models of neural development, learning, and memory. Although these models must incorporate algorithms that constrain synaptic weight changes, physiological evidence for such mechanisms is limited. Examination of LTP in area CA1 of the hippocampus revealed that the threshold for LTP induction was not fixed but could be strongly influenced by the recent history of synaptic activity. This effect was transient, synapse-specific, and dependent on postsynaptic N-methyl-D-aspartate (NMDA) receptor activation. These results suggest that the threshold for LTP induction may be continually adjusted according to the recent history of NMDA receptor activation and provide a physiological mechanism by which LTP can be transiently inhibited.