Genomic epidemiology of clinical Campylobacter spp. at a single health trust site
Genomic epidemiology of clinical Campylobacter spp. at a single health trust site
复制标题
DOI：
10.1099/mgen.0.000227
复制
发表时间：
2018-10-01
影响因子：
3.9
通讯作者：
Manning, Georgina
中科院分区：
文献类型：
--
作者：
Dunn, Steven J.;Pascoe, Ben;Manning, Georgina
弯曲杆菌是发达国家细菌性肠炎的主要原因，并且该生物体的感染在本质上主要是散发的。散发病例之间的联系尚未确定，大多数感染被认为是由遗传上不同的分离株引起的。使用读取映射方法，分析了2014年从大伯明翰地区收集的158株临床分离株，以评估当地人群结构，并调查弯曲杆菌病散发病例之间的潜在病例联系。在整个数据集中观察到4例（2.5%）病例关联。这项研究表明，散发性弯曲杆菌感染之间确实存在病例关联，并提供证据表明，弯曲杆菌基因组流行病学的双重多位点序列分型/谱系内单核苷酸多态性分型方法对公共卫生调查有益。
Campylobacter is the leading cause of bacterial enteritis in the developed world, and infections with the organism are largely sporadic in nature. Links between sporadic cases have not been established, with the majority of infections thought to be caused by genetically distinct isolates. Using a read-mapping approach, 158 clinical isolates collected during 2014 from the greater Nottinghamshire area were analysed to assess the local population structure and investigate potential case linkages between sporadic cases of campylobacteriosis. Four instances (2.5 %) of case linkage were observed across the dataset. This study demonstrates that case linkage does occur between sporadic Campylobacter infections, and provides evidence that a dual multi-locus sequence typing/within-lineage single nucleotide polymorphism typing approach to Campylobacter genomic epidemiology provides a benefit to public-health investigations.