Calcium sensor Yellow Cameleon 3.6 as a tool to support the calcium hypothesis of Alzheimer's disease.
Calcium sensor Yellow Cameleon 3.6 as a tool to support the calcium hypothesis of Alzheimer's disease.
复制标题
钙传感器 Yellow Cameleon 3.6 作为支持阿尔茨海默病钙假说的工具。
DOI：
10.1002/alz.13111
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Kastanenka,KseniaV
中科院分区：
文献类型：
--
作者：
Miller,MorganR;Lee,YeeFun;Kastanenka,KseniaV
简介阿尔茨海默病 (AD) 是一种神经退行性疾病，随着痴呆病例的增加，其相关性也越来越大。 AD 的病因学存在广泛争议。阿尔茨海默病和大脑衰老的钙假说指出，钙信号传导功能障碍是导致神经退行性变的最终共同途径。当钙假说最初被创造时，还没有测试它的技术，但随着 Yellow Cameleon 3.6 (YC3.6) 的出现，我们能够测试其有效性。方法这里我们回顾一下 YC3.6 在小鼠模型研究阿尔茨海默病中的应用，并讨论这些研究是否支持或反驳钙假说。结果YC3.6 研究表明，淀粉样变性先于神经元钙信号传导功能障碍和神经元钙信号传导功能障碍。突触结构。这一证据支持钙假说。讨论体内 YC3.6 研究指出钙信号传导是一个有前途的治疗靶点；然而，还需要开展更多工作才能将这些发现转化为人类。
INTRODUCTIONAlzheimer's disease (AD) is a neurodegenerative disease with increasing relevance as dementia cases rise. The etiology of AD is widely debated. TheCalcium Hypothesisof Alzheimer's disease and brain agingstates that the dysfunction of calcium signaling is the final common pathway leading to neurodegeneration. When the Calcium Hypothesis was originally coined, the technology did not exist to test it, but with the advent of Yellow Cameleon 3.6 (YC3.6) we are able to test its validity.METHODSHere we review use of YC3.6 in studying Alzheimer's disease using mouse models and discuss whether these studies support or refute the Calcium Hypothesis.RESULTSYC3.6 studies showed that amyloidosis preceded dysfunction in neuronal calcium signaling and changes in synapse structure. This evidence supports the Calcium Hypothesis.DISCUSSIONIn vivo YC3.6 studies point to calcium signaling as a promising therapeutic target; however, additional work is necessary to translate these findings to humans.