CHARACTERISTICS OF GADOLINIUM-DTPA COMPLEX - A POTENTIAL NMR CONTRAST AGENT
CHARACTERISTICS OF GADOLINIUM-DTPA COMPLEX - A POTENTIAL NMR CONTRAST AGENT
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DOI：
10.2214/ajr.142.3.619
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发表时间：
1984-01-01
影响因子：
5
通讯作者：
WESBEY, GE
中科院分区：
文献类型：
--
作者：
WEINMANN, HJ;BRASCH, RC;WESBEY, GE
稀土元素Gd与二乙三胺五乙酸(DTPA)的络合作用产生了一种在动物中很好耐受性的强顺磁性、稳定的络合物。强顺磁性的Gd络合物即使在低浓度(<；0.01 mmol/L)下也能缩短氢-质子弛豫时间。静脉注射的药代动力学行为。提供的Gd-DTPA类似于众所周知的用于尿路造影术和血管造影术的碘化造影剂。排泄主要通过肾脏，在24小时内恢复90%以上。Gd-DTPA葡胺盐对大鼠的LD_(50)为10 mmol/kg；在体内未发现Gd离子与DTPA配体解离的证据。强质子松弛、体内稳定性、快速尿液排泄和高耐受性的结合有利于Gd-DTPA作为磁共振成像对比剂的进一步发展和潜在的临床应用。
Chelation of the rare-earth element Gd with diethylenetriaminepentaacetic acid (DTPA) results in a strongly paramagnetic, stable complex that is well tolerated in animals. The strongly paramagnetic GD complex reduces hydrogen-proton relaxation times even in low concentrations (< 0.01 mmol/l). The pharmacokinetic behavior of i.v. delivered Gd-DTPA is similar to the well known iodinated contrast agents used in urography and angiography. Excretion is predominately through the kidneys with greater than 90% recovery in 24 h. The i.v. LD50 of the meglumine salt of Gd-DTPA is 10 mmol/kg for the rat; in vivo there is no evidence of dissociation of the GD ion from the DTPA ligand. The combination of strong proton relaxation, in-vivo stability, rapid urinary excretion and high tolerance favors the further development and the potential clinical application [in humans] of GD-DTPA as a contrast enhancer in magnetic resonance imaging.