Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents.
Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents.
复制标题
白三烯在哮喘中的作用。
作者：
L. Smith
最近的研究进展已经确定了哮喘的炎症成分。尽管许多内源性介质都与炎症有关，但白三烯似乎在哮喘中起着特别重要的作用。白三烯引起组织水肿、粘液分泌和平滑肌增生，并伴有强烈的支气管收缩。此外，抗白三烯药物已成为治疗哮喘的潜在药物。本研究旨在回顾这些新药物的最新信息。在这篇综述中，全文的文章抗白三烯药物进行了审查。这些文章是通过MEDLINE在以下医学标题下找到的：哮喘、炎症、白三烯、白三烯受体拮抗剂和白三烯合成抑制剂。被引用的大多数临床研究都是涉及健康个体和哮喘患者的安慰剂对照试验。这些研究表明，抗白三烯类药物可改善肺功能，减少哮喘症状和对额外药物的需求。抑制白三烯受体结合和白三烯合成的药物有望成为治疗哮喘的临床医生的新补充。此外，这些药物已经帮助阐明了哮喘病理生理特征的一些细节。
Recent advances in research have led to the identification of an inflammatory component to asthma. Although many endogenous mediators are involved in inflammation, leukotrienes appear to play an especially important role in asthma. The leukotrienes produce tissue edema, mucus secretion, and smooth-muscle proliferation, along with a powerful bronchoconstriction. In addition, antileukotriene drugs have emerged as potential therapeutic agents for asthma. This study was designed to review the current information on these new agents. In this review, full-length articles of antileukotriene agents are examined. These articles were found through MEDLINE under the following medical headings: asthma, inflammation, leukotriene, leukotriene-receptor antagonist, and leukotriene-synthesis inhibitor. Most clinical studies cited are placebo-controlled trials involving healthy individuals and patients with asthma. These studies indicate that antileukotriene agents improve lung function and reduce the symptoms of asthma and the need for additional medication. Drugs that inhibit leukotriene-receptor binding and leukotriene synthesis hold promise as new additions to the armamentarium of clinicians who treat asthma. Furthermore, these drugs have already helped to elucidate some details of the pathophysiological features of asthma.